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• W1894976307 abstract "Abstract A non-self-recognition system called vegetative incompatibility is ubiquitous in filamentous fungi and is genetically regulated by het loci. Different fungal individuals are unable to form viable heterokaryons if they differ in allelic specificity at a het locus. To identify components of vegetative incompatibility mediated by allelic differences at the het-c locus of Neurospora crassa, we isolated mutants that suppressed phenotypic aspects of het-c vegetative incompatibility. Three deletion mutants were identified; the deletions overlapped each other in an ORF named vib-1 (vegetative incompatibility blocked). Mutations in vib-1 fully relieved growth inhibition and repression of conidiation conferred by het-c vegetative incompatibility and significantly reduced hyphal compartmentation and death rates. The vib-1 mutants displayed a profuse conidiation pattern, suggesting that VIB-1 is a regulator of conidiation. VIB-1 shares a region of similarity to PHOG, a possible phosphate nonrepressible acid phosphatase in Aspergillus nidulans. Native gel analysis of wild-type strains and vib-1 mutants indicated that vib-1 is not the structural gene for nonrepressible acid phosphatase, but rather may regulate nonrepressible acid phosphatase activity." @default.
• W1894976307 created "2016-06-24" @default.
• W1894976307 creator A5056577532 @default.
• W1894976307 creator A5079342774 @default.
• W1894976307 date "2002-09-01" @default.
• W1894976307 modified "2023-10-11" @default.
• W1894976307 title "Identification of <i>vib-1</i>, a Locus Involved in Vegetative Incompatibility Mediated by <i>het-c</i> in <i>Neurospora crassa</i>" @default.
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• W1894976307 doi "https://doi.org/10.1093/genetics/162.1.89" @default.
• W1894976307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462268" @default.
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