FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1895018249> ?p ?o ?g. }

• W1895018249 endingPage "260" @default.
• W1895018249 startingPage "249" @default.
• W1895018249 abstract "Abstract Mutations in genes of Saccharomyces cerevisiae that code for proteins that interact with beta-tubulin were sought by screening for unlinked mutations that fail to complement mutations in the single beta-tubulin-encoding gene (TUB2). Among the first three noncomplementing mutations examined, two are linked to TUB2 while one is unlinked. The unlinked mutation was shown to be a conditional-lethal allele of the major alpha-tubulin-encoding gene (TUB1) and represents the first such mutation in that gene. The tub1-1 mutation itself causes a cold-sensitive cell-cycle arrest, and confers supersensitivity to the antimicrotubule drug benomyl. These phenotypes occur in the presence of a wild-type copy of the minor alpha-tubulin-encoding gene, TUB3; the combination of tub1-1 and a tub3 null mutation is inviable in haploids. Through further application of this method, new mutations in TUB2 and TUB3 were isolated as unlinked noncomplementers of tub1-1. The noncomplementation between tub1 and tub2 mutations is gene specific and allele specific, suggesting that the phenotype is due to an interaction at the protein level. We conclude that isolation of unlinked noncomplementing mutations is likely to be a generally useful method for isolating mutations in interacting gene products." @default.
• W1895018249 created "2016-06-24" @default.
• W1895018249 creator A5041641025 @default.
• W1895018249 creator A5077542898 @default.
• W1895018249 date "1988-06-01" @default.
• W1895018249 modified "2023-10-16" @default.
• W1895018249 title "Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae." @default.
• W1895018249 cites W1433017100 @default.
• W1895018249 cites W1519078080 @default.
• W1895018249 cites W1526043578 @default.
• W1895018249 cites W1749612483 @default.
• W1895018249 cites W1783140458 @default.
• W1895018249 cites W1812341569 @default.
• W1895018249 cites W1867104563 @default.
• W1895018249 cites W1867168887 @default.
• W1895018249 cites W1901276401 @default.
• W1895018249 cites W1920405460 @default.
• W1895018249 cites W1969737313 @default.
• W1895018249 cites W1973782344 @default.
• W1895018249 cites W1976576149 @default.
• W1895018249 cites W1987623343 @default.
• W1895018249 cites W1999917330 @default.
• W1895018249 cites W2028569284 @default.
• W1895018249 cites W2030076269 @default.
• W1895018249 cites W2032668403 @default.
• W1895018249 cites W2042464607 @default.
• W1895018249 cites W2043517704 @default.
• W1895018249 cites W2044605869 @default.
• W1895018249 cites W2047344741 @default.
• W1895018249 cites W2060397969 @default.
• W1895018249 cites W2074046561 @default.
• W1895018249 cites W2080918762 @default.
• W1895018249 cites W2083242648 @default.
• W1895018249 cites W2114217399 @default.
• W1895018249 cites W2133128874 @default.
• W1895018249 cites W2133433041 @default.
• W1895018249 cites W2148881591 @default.
• W1895018249 cites W2152125010 @default.
• W1895018249 cites W2161230893 @default.
• W1895018249 cites W2166028173 @default.
• W1895018249 cites W2236115149 @default.
• W1895018249 cites W2279299471 @default.
• W1895018249 cites W2400628512 @default.
• W1895018249 cites W2412776759 @default.
• W1895018249 cites W991504569 @default.
• W1895018249 doi "https://doi.org/10.1093/genetics/119.2.249" @default.
• W1895018249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1203409" @default.
• W1895018249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3294100" @default.
• W1895018249 hasPublicationYear "1988" @default.
• W1895018249 type Work @default.
• W1895018249 sameAs 1895018249 @default.
• W1895018249 citedByCount "175" @default.
• W1895018249 countsByYear W18950182492012 @default.
• W1895018249 countsByYear W18950182492013 @default.
• W1895018249 countsByYear W18950182492014 @default.
• W1895018249 countsByYear W18950182492015 @default.
• W1895018249 countsByYear W18950182492016 @default.
• W1895018249 countsByYear W18950182492017 @default.
• W1895018249 countsByYear W18950182492018 @default.
• W1895018249 countsByYear W18950182492019 @default.
• W1895018249 countsByYear W18950182492020 @default.
• W1895018249 crossrefType "journal-article" @default.
• W1895018249 hasAuthorship W1895018249A5041641025 @default.
• W1895018249 hasAuthorship W1895018249A5077542898 @default.
• W1895018249 hasBestOaLocation W18950182491 @default.
• W1895018249 hasConcept C104317684 @default.
• W1895018249 hasConcept C127716648 @default.
• W1895018249 hasConcept C180754005 @default.
• W1895018249 hasConcept C2777576037 @default.
• W1895018249 hasConcept C501734568 @default.
• W1895018249 hasConcept C54355233 @default.
• W1895018249 hasConcept C57708383 @default.
• W1895018249 hasConcept C86803240 @default.
• W1895018249 hasConcept C90630246 @default.
• W1895018249 hasConceptScore W1895018249C104317684 @default.
• W1895018249 hasConceptScore W1895018249C127716648 @default.
• W1895018249 hasConceptScore W1895018249C180754005 @default.
• W1895018249 hasConceptScore W1895018249C2777576037 @default.
• W1895018249 hasConceptScore W1895018249C501734568 @default.
• W1895018249 hasConceptScore W1895018249C54355233 @default.
• W1895018249 hasConceptScore W1895018249C57708383 @default.
• W1895018249 hasConceptScore W1895018249C86803240 @default.
• W1895018249 hasConceptScore W1895018249C90630246 @default.
• W1895018249 hasIssue "2" @default.
• W1895018249 hasLocation W18950182491 @default.
• W1895018249 hasLocation W18950182492 @default.
• W1895018249 hasOpenAccess W1895018249 @default.
• W1895018249 hasPrimaryLocation W18950182491 @default.
• W1895018249 hasRelatedWork W138964897 @default.
• W1895018249 hasRelatedWork W1895018249 @default.
• W1895018249 hasRelatedWork W1905321087 @default.
• W1895018249 hasRelatedWork W2013166796 @default.
• W1895018249 hasRelatedWork W2034211922 @default.
• W1895018249 hasRelatedWork W2044992835 @default.
• W1895018249 hasRelatedWork W2062255877 @default.
• W1895018249 hasRelatedWork W2068242723 @default.
• W1895018249 hasRelatedWork W2132322426 @default.
• W1895018249 hasRelatedWork W2149390511 @default.

• next