Matches in SemOpenAlex for { <https://semopenalex.org/work/W18954927> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W18954927 endingPage "6" @default.
- W18954927 startingPage "1311" @default.
- W18954927 abstract "A total of 334 HIV-infected patients with oral candidiasis were randomly assigned to receive 14 days of treatment with either 100 mg of oral fluconazole once daily or 10 mg clotrimazole five times daily. Both treatments were clinically effective: 98% of evaluable fluconazole-treated patients and 94% of evaluable clotrimazole-treated patients were cured or showed improvement (p = NS). Fluconazole was more effective than clotrimazole in eradicating Candida from the oral flora by the end of therapy (65% versus 48%) (p = 0.005). In addition, patients in the fluconazole-treated group were more likely to remain asymptomatic through the second week of follow-up (82.3% versus 50.0%) (p < 0.001). This difference was no longer evident by the post-therapy visit during week 4. Seven patients treated with clotrimazole and two patients treated with fluconazole discontinued therapy because of side effects. Two patients in the fluconazole group were withdrawn from therapy because of elevated serum glutamic-oxaloacetic transaminase levels, one considered possibly related to drug therapy. Fluconazole was as effective as clotrimazole in the treatment of oral candidiasis and temporarily provided a more prolonged disease-free state. Future studies are needed to define the optimal regimen for both the treatment and prevention of recurrent oral candidiasis in HIV-infected patients, addressing special attention to the issue of compliance, cost, and emergence of resistance." @default.
- W18954927 created "2016-06-24" @default.
- W18954927 creator A5003082375 @default.
- W18954927 creator A5017408918 @default.
- W18954927 creator A5056003566 @default.
- W18954927 date "1993-12-01" @default.
- W18954927 modified "2023-09-29" @default.
- W18954927 title "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." @default.
- W18954927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8254467" @default.
- W18954927 hasPublicationYear "1993" @default.
- W18954927 type Work @default.
- W18954927 sameAs 18954927 @default.
- W18954927 citedByCount "40" @default.
- W18954927 countsByYear W189549272012 @default.
- W18954927 countsByYear W189549272013 @default.
- W18954927 countsByYear W189549272015 @default.
- W18954927 countsByYear W189549272016 @default.
- W18954927 countsByYear W189549272021 @default.
- W18954927 countsByYear W189549272023 @default.
- W18954927 crossrefType "journal-article" @default.
- W18954927 hasAuthorship W18954927A5003082375 @default.
- W18954927 hasAuthorship W18954927A5017408918 @default.
- W18954927 hasAuthorship W18954927A5056003566 @default.
- W18954927 hasConcept C126322002 @default.
- W18954927 hasConcept C141071460 @default.
- W18954927 hasConcept C16005928 @default.
- W18954927 hasConcept C168563851 @default.
- W18954927 hasConcept C2777910003 @default.
- W18954927 hasConcept C2779548794 @default.
- W18954927 hasConcept C2780628323 @default.
- W18954927 hasConcept C2780651595 @default.
- W18954927 hasConcept C2780908437 @default.
- W18954927 hasConcept C2781413609 @default.
- W18954927 hasConcept C71924100 @default.
- W18954927 hasConcept C90924648 @default.
- W18954927 hasConceptScore W18954927C126322002 @default.
- W18954927 hasConceptScore W18954927C141071460 @default.
- W18954927 hasConceptScore W18954927C16005928 @default.
- W18954927 hasConceptScore W18954927C168563851 @default.
- W18954927 hasConceptScore W18954927C2777910003 @default.
- W18954927 hasConceptScore W18954927C2779548794 @default.
- W18954927 hasConceptScore W18954927C2780628323 @default.
- W18954927 hasConceptScore W18954927C2780651595 @default.
- W18954927 hasConceptScore W18954927C2780908437 @default.
- W18954927 hasConceptScore W18954927C2781413609 @default.
- W18954927 hasConceptScore W18954927C71924100 @default.
- W18954927 hasConceptScore W18954927C90924648 @default.
- W18954927 hasIssue "12" @default.
- W18954927 hasLocation W189549271 @default.
- W18954927 hasOpenAccess W18954927 @default.
- W18954927 hasPrimaryLocation W189549271 @default.
- W18954927 hasRelatedWork W18954927 @default.
- W18954927 hasRelatedWork W1973786578 @default.
- W18954927 hasRelatedWork W1974023935 @default.
- W18954927 hasRelatedWork W2043315439 @default.
- W18954927 hasRelatedWork W2151889248 @default.
- W18954927 hasRelatedWork W2321656772 @default.
- W18954927 hasRelatedWork W2397884650 @default.
- W18954927 hasRelatedWork W2414741993 @default.
- W18954927 hasRelatedWork W2466407277 @default.
- W18954927 hasRelatedWork W2678470159 @default.
- W18954927 hasVolume "6" @default.
- W18954927 isParatext "false" @default.
- W18954927 isRetracted "false" @default.
- W18954927 magId "18954927" @default.
- W18954927 workType "article" @default.