FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W189551320> ?p ?o ?g. }

• W189551320 endingPage "44" @default.
• W189551320 startingPage "33" @default.
• W189551320 abstract "With every heartbeat the heart must contract and relax. This seemingly trivial process critically needs tight control of contraction and relaxation phases, and extremely efficient coordination between these two phases to control blood flow and maintain cardiac homeostasis. To achieve this, specialized sensors are required to detect the inherent repeatedly changing environment and needs. One sensor is a stretch-sensor that monitors the filling of the ventricles. Its molecular identity and localization are only partly understood. Here we give a synopsis of the genetic models that leap into our understanding of stretch-sensors. We focus on the widely acknowledged sarcomeric sensor at the Z-disc and the costamere sensor at the sarcolemma. Recently, several novel components of both sensors were discovered. Given that these two sensors seem physically connected, it is likely that these two models are not mutually exclusive and might even communicate. We describe briefly how candidate and known proteins within these sensors receive and transduce mechanical signals in the cardiomyocyte that lead to changes in gene expression underlying homeostasis and its restoration in the heart. Emphasis is placed on the putative link between altered stretch-sensor function and heart failure observed in different genetic mouse models of stretch-sensor components." @default.
• W189551320 created "2016-06-24" @default.
• W189551320 creator A5010502376 @default.
• W189551320 creator A5028382724 @default.
• W189551320 creator A5029424457 @default.
• W189551320 creator A5031494737 @default.
• W189551320 creator A5041811551 @default.
• W189551320 date "2008-12-01" @default.
• W189551320 modified "2023-09-25" @default.
• W189551320 title "A broken heart: A stretch too far" @default.
• W189551320 cites W1485894565 @default.
• W189551320 cites W1486435880 @default.
• W189551320 cites W1549888790 @default.
• W189551320 cites W1819766005 @default.
• W189551320 cites W1964235198 @default.
• W189551320 cites W1964832022 @default.
• W189551320 cites W1966485417 @default.
• W189551320 cites W1966655531 @default.
• W189551320 cites W1970756392 @default.
• W189551320 cites W1972112857 @default.
• W189551320 cites W1973403849 @default.
• W189551320 cites W1975342294 @default.
• W189551320 cites W1975714515 @default.
• W189551320 cites W1977891434 @default.
• W189551320 cites W1980948443 @default.
• W189551320 cites W1982722271 @default.
• W189551320 cites W1985678297 @default.
• W189551320 cites W1989823141 @default.
• W189551320 cites W1989950796 @default.
• W189551320 cites W2004077739 @default.
• W189551320 cites W2005898155 @default.
• W189551320 cites W2011683654 @default.
• W189551320 cites W2012418580 @default.
• W189551320 cites W2017716708 @default.
• W189551320 cites W2023651395 @default.
• W189551320 cites W2026181894 @default.
• W189551320 cites W2028691987 @default.
• W189551320 cites W2034602137 @default.
• W189551320 cites W2036272929 @default.
• W189551320 cites W2036942148 @default.
• W189551320 cites W2041611268 @default.
• W189551320 cites W2044850263 @default.
• W189551320 cites W2047503478 @default.
• W189551320 cites W2047860205 @default.
• W189551320 cites W2048126905 @default.
• W189551320 cites W2050014442 @default.
• W189551320 cites W2052863274 @default.
• W189551320 cites W2055694197 @default.
• W189551320 cites W2056119944 @default.
• W189551320 cites W2060136332 @default.
• W189551320 cites W2061168934 @default.
• W189551320 cites W2061248737 @default.
• W189551320 cites W2061986589 @default.
• W189551320 cites W2065417808 @default.
• W189551320 cites W2065491098 @default.
• W189551320 cites W2067142765 @default.
• W189551320 cites W2068671266 @default.
• W189551320 cites W2071390801 @default.
• W189551320 cites W2071737186 @default.
• W189551320 cites W2072564164 @default.
• W189551320 cites W2077187719 @default.
• W189551320 cites W2080073058 @default.
• W189551320 cites W2080975812 @default.
• W189551320 cites W2082942293 @default.
• W189551320 cites W2084347012 @default.
• W189551320 cites W2091831926 @default.
• W189551320 cites W2093934431 @default.
• W189551320 cites W2094149101 @default.
• W189551320 cites W2094460966 @default.
• W189551320 cites W2097238233 @default.
• W189551320 cites W2097555314 @default.
• W189551320 cites W2098346778 @default.
• W189551320 cites W2098787491 @default.
• W189551320 cites W2104190934 @default.
• W189551320 cites W2104633662 @default.
• W189551320 cites W2105257979 @default.
• W189551320 cites W2106644177 @default.
• W189551320 cites W2107828221 @default.
• W189551320 cites W2111336754 @default.
• W189551320 cites W2111683138 @default.
• W189551320 cites W2112465301 @default.
• W189551320 cites W2112484130 @default.
• W189551320 cites W2115157006 @default.
• W189551320 cites W2115645521 @default.
• W189551320 cites W2116025920 @default.
• W189551320 cites W2116193546 @default.
• W189551320 cites W2117914440 @default.
• W189551320 cites W2121477456 @default.
• W189551320 cites W2122560124 @default.
• W189551320 cites W2122587656 @default.
• W189551320 cites W2122703252 @default.
• W189551320 cites W2123759534 @default.
• W189551320 cites W2125106118 @default.
• W189551320 cites W2125714022 @default.
• W189551320 cites W2127331541 @default.
• W189551320 cites W2128490069 @default.
• W189551320 cites W2130553995 @default.
• W189551320 cites W2132864654 @default.

• next