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• W1895900311 endingPage "3267" @default.
• W1895900311 startingPage "3259" @default.
• W1895900311 abstract "The interferon-induced double-stranded RNA-dependent eIF-2 alpha kinase (dsI) has an established role in mediating part of interferon's antiviral effects. Numerous studies have suggested that dsI also has regulatory functions in cells not infected with virus. Our previous results have indicated that the activation of this kinase may be an important regulatory signal in controlling growth arrest of mouse 3T3-F442A fibroblasts prior to their subsequent differentiation to adipocytes. Here, we report that extracts from 3T3-F442A cells cultured under conditions nonpermissive for differentiation exhibit significantly reduced dsI activity and that this reduction is due, at least in part, to the presence of elevated levels of a novel inhibitor of dsI activation (dRF). This inhibitor is also detected in reduced amounts in extracts from cells cultured under conditions which are permissive for differentiation. We have achieved a 1,000-fold purification of dRF activity, and highly purified dRF preparations were found to be greatly enriched for a 15-kDa protein that was greater than 90% pure. Our results indicate that dRF is not a protein phosphatase or protease but a reversible inhibitor of dsI autophosphorylation. In addition, our results imply that dRF is a physiologic regulator of dsI, since dRF activity correlates with the ability of 3T3-F442A cells to undergo adipose conversion." @default.
• W1895900311 created "2016-06-24" @default.
• W1895900311 creator A5027430240 @default.
• W1895900311 creator A5038389018 @default.
• W1895900311 date "1991-06-01" @default.
• W1895900311 modified "2023-09-26" @default.
• W1895900311 title "Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts." @default.
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• W1895900311 doi "https://doi.org/10.1128/mcb.11.6.3259" @default.
• W1895900311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/360178" @default.
• W1895900311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1674819" @default.
• W1895900311 hasPublicationYear "1991" @default.
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