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• W189595587 abstract "It was observed that norepinephrine (NE) was associated with sedimentable material in peripheral noradrenergic neurons. Since that time, the properties of the particles that contain NE have been investigated using morphological and biochemical techniques. It appears that NE is stored in several types of subcellular organelles. Examination of adrenergic neurons by electron microscopy has revealed large, dense-cored vesicles. The electron lucent vesicles appear to be able to take up exogenous analogues of NE such as 5-hydroxydopamine. Morphological evidence suggests that NE is stored in a tubular reticulum-like structure, which has a reserpine sensitive core. The existence of several types of NE storage vesicles in adrenergic neurons is accepted. There is less agreement with regard to the type and distribution of storage particles that are found in nerve terminals. NE was associated with dense and light vesicles while dopamine-β-hydroxylase (DBH) activity was associated only with the denser vesicle fraction. This result suggests that there are two populations of vesicles in the dog spleen capable of storing NE but that only the denser of the two can function to synthesize this amine." @default.
• W189595587 created "2016-06-24" @default.
• W189595587 creator A5033809000 @default.
• W189595587 creator A5045637861 @default.
• W189595587 date "1976-01-01" @default.
• W189595587 modified "2023-09-27" @default.
• W189595587 title "EFFECTS OF PHYSIOLOGICAL AND PHARMACOLOGICAL STRESS ON THE SUBCELLULAR DISTRIBUTION OF ADRENERGIC STORAGE VESICLES IN RAT HEART11Supported by the USPHS (NS 10206 and 5 T0L G-M0 1983)." @default.
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• W189595587 doi "https://doi.org/10.1016/b978-0-08-020588-5.50057-6" @default.
• W189595587 hasPublicationYear "1976" @default.
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