FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1896420201> ?p ?o ?g. }

• W1896420201 endingPage "2331" @default.
• W1896420201 startingPage "2321" @default.
• W1896420201 abstract "The triple-negative breast cancer (TNBC) subtype represents a cancer that is highly aggressive with poor patient outcome. Current preclinical success has been gained through synthetic lethality, targeting genome instability with PARP inhibition in breast cancer cells that harbor silencing of the homologous recombination (HR) pathway. Histone deacetylase inhibitors (HDACi) are a class of drugs that mediate epigenetic changes in expression of HR pathway genes. Here, we compare the activity of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA), the class I/IIa HDAC inhibitor valproic acid (VPA), and the HDAC1/2-specific inhibitor romidepsin (ROMI) for their capability to regulate DNA damage repair gene expression and in sensitizing TNBC to PARPi. We found that two of the HDACis tested, SAHA and ROMI, but not VPA, indeed inhibit HR repair and that RAD51, BARD1, and FANCD2 represent key proteins whose inhibition is required for HDACi-mediated therapy with PARP inhibition in TNBC. We also observed that restoration of BRCA1 function stabilizes the genome compared with mutant BRCA1 that results in enhanced polyploid population after combination treatment with HDACi and PARPi. Furthermore, we found that overexpression of the key HR protein RAD51 represents a mechanism for this resistance, promoting aberrant repair and the enhanced polyploidy observed. These findings highlight the key components of HR in guiding synthetic lethality with PARP inhibition and support the rationale for utilizing the novel combination of HDACi and PARPi against TNBC in the clinical setting." @default.
• W1896420201 created "2016-06-24" @default.
• W1896420201 creator A5006478706 @default.
• W1896420201 creator A5042627450 @default.
• W1896420201 creator A5075523186 @default.
• W1896420201 creator A5080589100 @default.
• W1896420201 creator A5088521436 @default.
• W1896420201 date "2015-10-01" @default.
• W1896420201 modified "2023-10-01" @default.
• W1896420201 title "Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition" @default.
• W1896420201 cites W1491750953 @default.
• W1896420201 cites W1969513645 @default.
• W1896420201 cites W1973268287 @default.
• W1896420201 cites W1982957001 @default.
• W1896420201 cites W1993043513 @default.
• W1896420201 cites W2006067987 @default.
• W1896420201 cites W2008650297 @default.
• W1896420201 cites W2018460886 @default.
• W1896420201 cites W2020091112 @default.
• W1896420201 cites W2020382936 @default.
• W1896420201 cites W2020388204 @default.
• W1896420201 cites W2022309076 @default.
• W1896420201 cites W2026007913 @default.
• W1896420201 cites W2026355284 @default.
• W1896420201 cites W2028637581 @default.
• W1896420201 cites W2031707965 @default.
• W1896420201 cites W2032679606 @default.
• W1896420201 cites W2044570206 @default.
• W1896420201 cites W2047277968 @default.
• W1896420201 cites W2053822327 @default.
• W1896420201 cites W2058322286 @default.
• W1896420201 cites W2069019880 @default.
• W1896420201 cites W2073569331 @default.
• W1896420201 cites W2073999186 @default.
• W1896420201 cites W2085053844 @default.
• W1896420201 cites W2090418179 @default.
• W1896420201 cites W2091309325 @default.
• W1896420201 cites W2096055355 @default.
• W1896420201 cites W2100462151 @default.
• W1896420201 cites W2106671241 @default.
• W1896420201 cites W2116735990 @default.
• W1896420201 cites W2119569174 @default.
• W1896420201 cites W2130447102 @default.
• W1896420201 cites W2134539328 @default.
• W1896420201 cites W2135721953 @default.
• W1896420201 cites W2137755195 @default.
• W1896420201 cites W2142658272 @default.
• W1896420201 cites W2143658931 @default.
• W1896420201 cites W2158338569 @default.
• W1896420201 cites W2162114093 @default.
• W1896420201 cites W2164682636 @default.
• W1896420201 cites W2170476788 @default.
• W1896420201 cites W96330505 @default.
• W1896420201 doi "https://doi.org/10.1158/1535-7163.mct-15-0374" @default.
• W1896420201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26294743" @default.
• W1896420201 hasPublicationYear "2015" @default.
• W1896420201 type Work @default.
• W1896420201 sameAs 1896420201 @default.
• W1896420201 citedByCount "39" @default.
• W1896420201 countsByYear W18964202012016 @default.
• W1896420201 countsByYear W18964202012017 @default.
• W1896420201 countsByYear W18964202012018 @default.
• W1896420201 countsByYear W18964202012019 @default.
• W1896420201 countsByYear W18964202012020 @default.
• W1896420201 countsByYear W18964202012021 @default.
• W1896420201 countsByYear W18964202012022 @default.
• W1896420201 countsByYear W18964202012023 @default.
• W1896420201 crossrefType "journal-article" @default.
• W1896420201 hasAuthorship W1896420201A5006478706 @default.
• W1896420201 hasAuthorship W1896420201A5042627450 @default.
• W1896420201 hasAuthorship W1896420201A5075523186 @default.
• W1896420201 hasAuthorship W1896420201A5080589100 @default.
• W1896420201 hasAuthorship W1896420201A5088521436 @default.
• W1896420201 hasBestOaLocation W18964202011 @default.
• W1896420201 hasConcept C102744134 @default.
• W1896420201 hasConcept C104317684 @default.
• W1896420201 hasConcept C134935766 @default.
• W1896420201 hasConcept C143425029 @default.
• W1896420201 hasConcept C178169997 @default.
• W1896420201 hasConcept C182979987 @default.
• W1896420201 hasConcept C2776202225 @default.
• W1896420201 hasConcept C2778305200 @default.
• W1896420201 hasConcept C2778480876 @default.
• W1896420201 hasConcept C2778502085 @default.
• W1896420201 hasConcept C2779012473 @default.
• W1896420201 hasConcept C2779138821 @default.
• W1896420201 hasConcept C2779962180 @default.
• W1896420201 hasConcept C2780225316 @default.
• W1896420201 hasConcept C2781462825 @default.
• W1896420201 hasConcept C41091548 @default.
• W1896420201 hasConcept C502942594 @default.
• W1896420201 hasConcept C54355233 @default.
• W1896420201 hasConcept C552990157 @default.
• W1896420201 hasConcept C64927066 @default.
• W1896420201 hasConcept C82381507 @default.
• W1896420201 hasConcept C86803240 @default.
• W1896420201 hasConceptScore W1896420201C102744134 @default.
• W1896420201 hasConceptScore W1896420201C104317684 @default.

• next