Matches in SemOpenAlex for { <https://semopenalex.org/work/W1896531240> ?p ?o ?g. }
- W1896531240 endingPage "5487" @default.
- W1896531240 startingPage "5480" @default.
- W1896531240 abstract "Abstract Dendritic cells (DC), the most potent APCs, can initiate the immune response or help induce immune tolerance, depending upon their level of maturation. DC maturation is associated with activation of the NF-κB pathway, and the primary NF-κB protein involved in DC maturation is RelB, which coordinates RelA/p50-mediated DC differentiation. In this study, we show that silencing RelB using small interfering RNA results in arrest of DC maturation with reduced expression of the MHC class II, CD80, and CD86. Functionally, RelB-silenced DC inhibited MLR, and inhibitory effects on alloreactive immune responses were in an Ag-specific fashion. RelB-silenced DC also displayed strong in vivo immune regulation. An inhibited Ag-specific response was seen after immunization with keyhole limpet hemocyanin-pulsed and RelB-silenced DC, due to the expansion of T regulatory cells. Administration of donor-derived RelB-silenced DC significantly prevented allograft rejection in murine heart transplantation. This study demonstrates for the first time that transplant tolerance can be induced by means of RNA interference using in vitro-generated tolerogenic DC." @default.
- W1896531240 created "2016-06-24" @default.
- W1896531240 creator A5004840287 @default.
- W1896531240 creator A5012386466 @default.
- W1896531240 creator A5014117294 @default.
- W1896531240 creator A5020449897 @default.
- W1896531240 creator A5025788211 @default.
- W1896531240 creator A5037082551 @default.
- W1896531240 creator A5045158657 @default.
- W1896531240 creator A5051065845 @default.
- W1896531240 creator A5053151348 @default.
- W1896531240 creator A5059623836 @default.
- W1896531240 creator A5077157954 @default.
- W1896531240 creator A5078260184 @default.
- W1896531240 creator A5083492992 @default.
- W1896531240 creator A5086710806 @default.
- W1896531240 date "2007-05-01" @default.
- W1896531240 modified "2023-09-24" @default.
- W1896531240 title "Immune Modulation and Tolerance Induction by RelB-Silenced Dendritic Cells through RNA Interference" @default.
- W1896531240 cites W108224684 @default.
- W1896531240 cites W1486389597 @default.
- W1896531240 cites W1561535731 @default.
- W1896531240 cites W1571190010 @default.
- W1896531240 cites W1608611033 @default.
- W1896531240 cites W1611419331 @default.
- W1896531240 cites W1647075334 @default.
- W1896531240 cites W1651589626 @default.
- W1896531240 cites W1935100605 @default.
- W1896531240 cites W1972746775 @default.
- W1896531240 cites W1972758309 @default.
- W1896531240 cites W1973522434 @default.
- W1896531240 cites W1975284062 @default.
- W1896531240 cites W1982906491 @default.
- W1896531240 cites W1987887264 @default.
- W1896531240 cites W1993102343 @default.
- W1896531240 cites W1997055154 @default.
- W1896531240 cites W1997512963 @default.
- W1896531240 cites W2002905931 @default.
- W1896531240 cites W2003967727 @default.
- W1896531240 cites W2006195111 @default.
- W1896531240 cites W2007751085 @default.
- W1896531240 cites W2014003694 @default.
- W1896531240 cites W2018718597 @default.
- W1896531240 cites W2028016355 @default.
- W1896531240 cites W2029348411 @default.
- W1896531240 cites W2031876792 @default.
- W1896531240 cites W2033810895 @default.
- W1896531240 cites W2036396320 @default.
- W1896531240 cites W2041406972 @default.
- W1896531240 cites W2043326409 @default.
- W1896531240 cites W2045277695 @default.
- W1896531240 cites W2047860183 @default.
- W1896531240 cites W2053188239 @default.
- W1896531240 cites W2055997031 @default.
- W1896531240 cites W2057793002 @default.
- W1896531240 cites W2057917442 @default.
- W1896531240 cites W2074121520 @default.
- W1896531240 cites W2076361525 @default.
- W1896531240 cites W2078275150 @default.
- W1896531240 cites W2078725645 @default.
- W1896531240 cites W2079432889 @default.
- W1896531240 cites W2090128233 @default.
- W1896531240 cites W2091420555 @default.
- W1896531240 cites W2102689053 @default.
- W1896531240 cites W2106382467 @default.
- W1896531240 cites W2110327819 @default.
- W1896531240 cites W2114735542 @default.
- W1896531240 cites W2116763454 @default.
- W1896531240 cites W2128212057 @default.
- W1896531240 cites W2131208717 @default.
- W1896531240 cites W2133433794 @default.
- W1896531240 cites W2138961639 @default.
- W1896531240 cites W2139423334 @default.
- W1896531240 cites W2139557613 @default.
- W1896531240 cites W2141575322 @default.
- W1896531240 cites W2152398830 @default.
- W1896531240 cites W2154610258 @default.
- W1896531240 cites W2155612281 @default.
- W1896531240 cites W2161354474 @default.
- W1896531240 cites W2161899228 @default.
- W1896531240 cites W2162415302 @default.
- W1896531240 cites W2169457025 @default.
- W1896531240 cites W2186367580 @default.
- W1896531240 cites W2329263004 @default.
- W1896531240 cites W4246084324 @default.
- W1896531240 cites W4252988027 @default.
- W1896531240 doi "https://doi.org/10.4049/jimmunol.178.9.5480" @default.
- W1896531240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17442929" @default.
- W1896531240 hasPublicationYear "2007" @default.
- W1896531240 type Work @default.
- W1896531240 sameAs 1896531240 @default.
- W1896531240 citedByCount "114" @default.
- W1896531240 countsByYear W18965312402012 @default.
- W1896531240 countsByYear W18965312402013 @default.
- W1896531240 countsByYear W18965312402014 @default.
- W1896531240 countsByYear W18965312402015 @default.
- W1896531240 countsByYear W18965312402016 @default.
- W1896531240 countsByYear W18965312402017 @default.