FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1896753574> ?p ?o ?g. }

• W1896753574 endingPage "2439" @default.
• W1896753574 startingPage "2431" @default.
• W1896753574 abstract "Development of the mammalian male accessory sexual organs requires both androgens and mesenchymal/epithelial interactions. Paracrine acting factors whose expression is mesenchymal and androgen dependent have been proposed to regulate development of these organs, although the identity of these paracrine mediators is unknown. Keratinocyte growth factor (Kgf) has been shown to play an important role in the development of the mouse seminal vesicle and rat ventral prostate. Also, Kgf is expressed in mesenchymal cells and has been shown to be regulated by androgens in prostatic cells grown in vitro. Thus Kgf has been proposed as a mediator of androgen action. We have investigated the expression of Kgf mRNA during development of the rat seminal vesicle and prostate, both in vitro and in vivo. Additionally we have examined mRNAs for Kgf receptor (KgfR), transforming growth factor alpha (Tgf alpha), epidermal growth factor receptor (EgfR) and cytokeratin 19 (CK19). The levels of growth factor and receptor mRNAs fluctuated during androgen-regulated development; however, these changes reflected variations in the mesenchymal/epithelial ratio rather than regulation by testosterone. Expression of Kgf is mesenchymal, while KgfR is epithelial and Tgf alpha is predominantly epithelial. The changes in the levels of mRNAs for these factors correlated well with changes in the level of an epithelial marker, CK19, suggesting they were due to alterations in the relative abundance of tissue compartments in which they were expressed. Kgf has been shown to mimic androgen action in explant cultures of seminal vesicle and prostate. We demonstrate here that anti-androgens are able to block Kgf stimulated development, suggesting that Kgf and androgen receptor signalling pathways may interact. Taken together our data suggest that, in vivo, Kgf may interact with androgen receptor signalling but it is not a direct target of androgen action." @default.
• W1896753574 created "2016-06-24" @default.
• W1896753574 creator A5001441690 @default.
• W1896753574 creator A5046074056 @default.
• W1896753574 creator A5065328069 @default.
• W1896753574 date "1997-06-15" @default.
• W1896753574 modified "2023-10-14" @default.
• W1896753574 title "Analysis of growth factor and receptor mRNA levels during development of the rat seminal vesicle and prostate" @default.
• W1896753574 cites W1829274477 @default.
• W1896753574 cites W1906845940 @default.
• W1896753574 cites W1965768875 @default.
• W1896753574 cites W1980398407 @default.
• W1896753574 cites W1997348862 @default.
• W1896753574 cites W1998902718 @default.
• W1896753574 cites W2005205814 @default.
• W1896753574 cites W2005287015 @default.
• W1896753574 cites W2005615385 @default.
• W1896753574 cites W2011511955 @default.
• W1896753574 cites W2022467685 @default.
• W1896753574 cites W2031146912 @default.
• W1896753574 cites W2038704446 @default.
• W1896753574 cites W2041434453 @default.
• W1896753574 cites W2043408634 @default.
• W1896753574 cites W2050918242 @default.
• W1896753574 cites W2059295683 @default.
• W1896753574 cites W2071607446 @default.
• W1896753574 cites W2084816867 @default.
• W1896753574 cites W2093325301 @default.
• W1896753574 cites W2106059813 @default.
• W1896753574 cites W2107706859 @default.
• W1896753574 cites W2131986778 @default.
• W1896753574 cites W2141790367 @default.
• W1896753574 doi "https://doi.org/10.1242/dev.124.12.2431" @default.
• W1896753574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9199369" @default.
• W1896753574 hasPublicationYear "1997" @default.
• W1896753574 type Work @default.
• W1896753574 sameAs 1896753574 @default.
• W1896753574 citedByCount "85" @default.
• W1896753574 countsByYear W18967535742012 @default.
• W1896753574 countsByYear W18967535742013 @default.
• W1896753574 countsByYear W18967535742014 @default.
• W1896753574 countsByYear W18967535742015 @default.
• W1896753574 countsByYear W18967535742017 @default.
• W1896753574 countsByYear W18967535742019 @default.
• W1896753574 countsByYear W18967535742021 @default.
• W1896753574 crossrefType "journal-article" @default.
• W1896753574 hasAuthorship W1896753574A5001441690 @default.
• W1896753574 hasAuthorship W1896753574A5046074056 @default.
• W1896753574 hasAuthorship W1896753574A5065328069 @default.
• W1896753574 hasBestOaLocation W18967535741 @default.
• W1896753574 hasConcept C121608353 @default.
• W1896753574 hasConcept C126322002 @default.
• W1896753574 hasConcept C134018914 @default.
• W1896753574 hasConcept C170493617 @default.
• W1896753574 hasConcept C198826908 @default.
• W1896753574 hasConcept C2775960820 @default.
• W1896753574 hasConcept C2776235491 @default.
• W1896753574 hasConcept C2776362946 @default.
• W1896753574 hasConcept C2777911890 @default.
• W1896753574 hasConcept C2778615670 @default.
• W1896753574 hasConcept C2780192828 @default.
• W1896753574 hasConcept C2781171107 @default.
• W1896753574 hasConcept C54355233 @default.
• W1896753574 hasConcept C55493867 @default.
• W1896753574 hasConcept C61367390 @default.
• W1896753574 hasConcept C71315377 @default.
• W1896753574 hasConcept C71924100 @default.
• W1896753574 hasConcept C7876069 @default.
• W1896753574 hasConcept C86803240 @default.
• W1896753574 hasConcept C95444343 @default.
• W1896753574 hasConceptScore W1896753574C121608353 @default.
• W1896753574 hasConceptScore W1896753574C126322002 @default.
• W1896753574 hasConceptScore W1896753574C134018914 @default.
• W1896753574 hasConceptScore W1896753574C170493617 @default.
• W1896753574 hasConceptScore W1896753574C198826908 @default.
• W1896753574 hasConceptScore W1896753574C2775960820 @default.
• W1896753574 hasConceptScore W1896753574C2776235491 @default.
• W1896753574 hasConceptScore W1896753574C2776362946 @default.
• W1896753574 hasConceptScore W1896753574C2777911890 @default.
• W1896753574 hasConceptScore W1896753574C2778615670 @default.
• W1896753574 hasConceptScore W1896753574C2780192828 @default.
• W1896753574 hasConceptScore W1896753574C2781171107 @default.
• W1896753574 hasConceptScore W1896753574C54355233 @default.
• W1896753574 hasConceptScore W1896753574C55493867 @default.
• W1896753574 hasConceptScore W1896753574C61367390 @default.
• W1896753574 hasConceptScore W1896753574C71315377 @default.
• W1896753574 hasConceptScore W1896753574C71924100 @default.
• W1896753574 hasConceptScore W1896753574C7876069 @default.
• W1896753574 hasConceptScore W1896753574C86803240 @default.
• W1896753574 hasConceptScore W1896753574C95444343 @default.
• W1896753574 hasIssue "12" @default.
• W1896753574 hasLocation W18967535741 @default.
• W1896753574 hasLocation W18967535742 @default.
• W1896753574 hasOpenAccess W1896753574 @default.
• W1896753574 hasPrimaryLocation W18967535741 @default.
• W1896753574 hasRelatedWork W1985227958 @default.
• W1896753574 hasRelatedWork W2004261902 @default.
• W1896753574 hasRelatedWork W2021560856 @default.

• next