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• W1896851419 endingPage "S157" @default.
• W1896851419 startingPage "S154" @default.
• W1896851419 abstract "Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the regulation of the inflammatory response, growth and cell differentiation. Elevated GDF-15 was found in patients with established CV diseases including hypertension, stable coronary artery disease, acute coronary syndrome, myocardial infarction, ischemic and none ischemic-induced cardiomyopathies, heart failure, atrial fibrillation, as well as stroke, type two diabetes mellitus (T2DM), chronic kidney disease, infection, liver cirrhosis, malignancy. Therefore, aging, smoking, and various environmental factors, i.e. chemical pollutants are other risk factors that might increase serum GDF-15 level. Although GDF-15 has been reported to be involved in energy homoeostasis and weight loss, to have anti-inflammatory properties, and to predict CV diseases and CV events in general or established CV disease population, there is no large of body of evidence regarding predictive role of elevated GDF-15 in T2DM subjects. The mini review is clarified the role of GDF-15 in T2DM subjects." @default.
• W1896851419 created "2016-06-24" @default.
• W1896851419 creator A5038242220 @default.
• W1896851419 date "2016-01-01" @default.
• W1896851419 modified "2023-10-13" @default.
• W1896851419 title "Diabetes mellitus related biomarker: The predictive role of growth-differentiation factor-15" @default.
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• W1896851419 doi "https://doi.org/10.1016/j.dsx.2015.09.016" @default.
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• W1896851419 hasPublicationYear "2016" @default.
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