Matches in SemOpenAlex for { <https://semopenalex.org/work/W1896954547> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1896954547 endingPage "54" @default.
- W1896954547 startingPage "49" @default.
- W1896954547 abstract "It is known that opioids inhibit the hypoxic ventilatory response in part via an action at the carotid body, but little is known about the cellular mechanisms that underpin this. This study's objectives were to examine which opioid receptors are located on the oxygen-sensing carotid body type I cells from the rat and determine the mechanism by which opioids might inhibit cellular excitability.Immunocytochemistry revealed the presence of μ and κ opioid receptors on type I cells. The μ-selective agonist DAMGO (10 μM) and the κ-selective agonist U50-488 (10 μM) inhibited high K(+) induced rises in intracellular Ca(2+) compared with controls. After 3 h incubation (37 °C) with pertussis toxin (150 ng ml(-1)), DAMGO (10 μM) and U50-488 (10 μM) had no significant effect on the Ca(2+) response to high K(+).These results indicate that opioids acting at μ and κ receptors inhibit voltage-gated Ca(2+) influx in rat carotid body type I cells via G(i)-coupled mechanisms. This mechanism may contribute to opioid's inhibitory actions in the carotid body." @default.
- W1896954547 created "2016-06-24" @default.
- W1896954547 creator A5041323934 @default.
- W1896954547 creator A5044742154 @default.
- W1896954547 creator A5052152189 @default.
- W1896954547 creator A5055490918 @default.
- W1896954547 date "2015-01-01" @default.
- W1896954547 modified "2023-09-30" @default.
- W1896954547 title "Selective mu and kappa Opioid Agonists Inhibit Voltage-Gated Ca2+ Entry in Isolated Neonatal Rat Carotid Body Type I Cells" @default.
- W1896954547 cites W1965902219 @default.
- W1896954547 cites W2027243414 @default.
- W1896954547 cites W2030007409 @default.
- W1896954547 cites W2042172922 @default.
- W1896954547 cites W2050651031 @default.
- W1896954547 cites W2068642420 @default.
- W1896954547 cites W2084299069 @default.
- W1896954547 cites W2115145156 @default.
- W1896954547 cites W2147243399 @default.
- W1896954547 cites W2235671932 @default.
- W1896954547 doi "https://doi.org/10.1007/978-3-319-18440-1_6" @default.
- W1896954547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26303466" @default.
- W1896954547 hasPublicationYear "2015" @default.
- W1896954547 type Work @default.
- W1896954547 sameAs 1896954547 @default.
- W1896954547 citedByCount "5" @default.
- W1896954547 countsByYear W18969545472017 @default.
- W1896954547 countsByYear W18969545472018 @default.
- W1896954547 countsByYear W18969545472021 @default.
- W1896954547 countsByYear W18969545472022 @default.
- W1896954547 crossrefType "book-chapter" @default.
- W1896954547 hasAuthorship W1896954547A5041323934 @default.
- W1896954547 hasAuthorship W1896954547A5044742154 @default.
- W1896954547 hasAuthorship W1896954547A5052152189 @default.
- W1896954547 hasAuthorship W1896954547A5055490918 @default.
- W1896954547 hasConcept C126322002 @default.
- W1896954547 hasConcept C134018914 @default.
- W1896954547 hasConcept C14397066 @default.
- W1896954547 hasConcept C170493617 @default.
- W1896954547 hasConcept C185263204 @default.
- W1896954547 hasConcept C185592680 @default.
- W1896954547 hasConcept C2776401185 @default.
- W1896954547 hasConcept C2778113364 @default.
- W1896954547 hasConcept C2778938600 @default.
- W1896954547 hasConcept C2779886867 @default.
- W1896954547 hasConcept C2781063702 @default.
- W1896954547 hasConcept C49773422 @default.
- W1896954547 hasConcept C55493867 @default.
- W1896954547 hasConcept C71924100 @default.
- W1896954547 hasConcept C79879829 @default.
- W1896954547 hasConcept C80631254 @default.
- W1896954547 hasConcept C86803240 @default.
- W1896954547 hasConcept C98274493 @default.
- W1896954547 hasConceptScore W1896954547C126322002 @default.
- W1896954547 hasConceptScore W1896954547C134018914 @default.
- W1896954547 hasConceptScore W1896954547C14397066 @default.
- W1896954547 hasConceptScore W1896954547C170493617 @default.
- W1896954547 hasConceptScore W1896954547C185263204 @default.
- W1896954547 hasConceptScore W1896954547C185592680 @default.
- W1896954547 hasConceptScore W1896954547C2776401185 @default.
- W1896954547 hasConceptScore W1896954547C2778113364 @default.
- W1896954547 hasConceptScore W1896954547C2778938600 @default.
- W1896954547 hasConceptScore W1896954547C2779886867 @default.
- W1896954547 hasConceptScore W1896954547C2781063702 @default.
- W1896954547 hasConceptScore W1896954547C49773422 @default.
- W1896954547 hasConceptScore W1896954547C55493867 @default.
- W1896954547 hasConceptScore W1896954547C71924100 @default.
- W1896954547 hasConceptScore W1896954547C79879829 @default.
- W1896954547 hasConceptScore W1896954547C80631254 @default.
- W1896954547 hasConceptScore W1896954547C86803240 @default.
- W1896954547 hasConceptScore W1896954547C98274493 @default.
- W1896954547 hasLocation W18969545471 @default.
- W1896954547 hasLocation W18969545472 @default.
- W1896954547 hasOpenAccess W1896954547 @default.
- W1896954547 hasPrimaryLocation W18969545471 @default.
- W1896954547 hasRelatedWork W1939982962 @default.
- W1896954547 hasRelatedWork W1966153991 @default.
- W1896954547 hasRelatedWork W1968272849 @default.
- W1896954547 hasRelatedWork W1976394800 @default.
- W1896954547 hasRelatedWork W1981806124 @default.
- W1896954547 hasRelatedWork W2063729949 @default.
- W1896954547 hasRelatedWork W2091827449 @default.
- W1896954547 hasRelatedWork W2110133277 @default.
- W1896954547 hasRelatedWork W2158448658 @default.
- W1896954547 hasRelatedWork W2441241457 @default.
- W1896954547 isParatext "false" @default.
- W1896954547 isRetracted "false" @default.
- W1896954547 magId "1896954547" @default.
- W1896954547 workType "book-chapter" @default.