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• W189697544 abstract "Ethyl, 6-Heptyl) Phenol (EHP), a biologically active compound formerly extracted by benzene from Cuminum cyminum (cumin) Egyptian seeds and of activity against a number of fungal pathogens, exhibited antitumor activity against six types of tumor cell lines (HEPG2, HELA, HCT116, MCF7, HEP2, CACO2). EHP showed no cytotoxicity when its activity was investigated on the normal fibroblast cell line (BHK). MCF7 was the most sensitive tumor cell line where only 33% of the cells survived followed by HEPG2 (41 % of the cells survived) and HEP2 (56% of the cells survived) at an EHP concentration of 10μ g/ml. The percentage of tumor cell survival of CACO2 and HCT116 was 72% and76% respectively exhibiting much less activity, however EHP activity against HELA was negligible. EHP activity was also investigated against eight bacterial human pathogens (four Gram-positive and four Gram-negative ones). Higher activity was observed against Gram-positive bacteria than Gram-negative ones where Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis and Bacillus thuringiensis were more sensitive than Salmonella typhi, Escherichia coli, Serratia marcescens and Pseudomonas aeruginosa. This study directs the attention to the antifungal, antibacterial and antitumor benefits of the cheap, safe, available and tasteful cumin." @default.
• W189697544 created "2016-06-24" @default.
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• W189697544 date "2009-01-01" @default.
• W189697544 modified "2023-09-24" @default.
• W189697544 title "Antitumor and Antibacterial Activities of (1-(2-Ethyl, 6-Heptyl) Phenol) from Cuminum Cyminum Seeds" @default.
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