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- W1897002012 abstract "Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, to the immature developing lung that causes arrested lung development.The thioredoxin (Trx) system, which is predominantly expressed in pulmonary epithelia in the newborn lung, acts as an antioxidant system; however, it is increasingly recognized as a key redox regulator of signal transduction and gene expression via thiol-disulfide exchange reactions.This review focuses on the contribution of Trx family proteins toward normal and aberrant lung development, in particular, the roles of the Trx system in hyperoxic responses of alveolar epithelial cells, aberrant lung development in animal models of BPD, O2-dependent signaling processes, and possible therapeutic efficacy in preventing O2-mediated lung injury.The significant contribution of the Trx system toward redox regulation of key developmental pathways necessary for proper lung development suggests that therapeutic strategies focused on preserving pulmonary Trx function could significantly improve the outcomes of prematurely born human infants." @default.
- W1897002012 created "2016-06-24" @default.
- W1897002012 creator A5090352230 @default.
- W1897002012 date "2014-11-01" @default.
- W1897002012 modified "2023-10-16" @default.
- W1897002012 title "The Thioredoxin System in Neonatal Lung Disease" @default.
- W1897002012 cites W120058826 @default.
- W1897002012 cites W1501442799 @default.
- W1897002012 cites W1516755848 @default.
- W1897002012 cites W1519698555 @default.
- W1897002012 cites W1531916091 @default.
- W1897002012 cites W1551392207 @default.
- W1897002012 cites W1555938743 @default.
- W1897002012 cites W1963945616 @default.
- W1897002012 cites W1969268163 @default.
- W1897002012 cites W1969310772 @default.
- W1897002012 cites W1970939192 @default.
- W1897002012 cites W1970976586 @default.
- W1897002012 cites W1980733086 @default.
- W1897002012 cites W1984568177 @default.
- W1897002012 cites W1986204853 @default.
- W1897002012 cites W1991387227 @default.
- W1897002012 cites W1991568967 @default.
- W1897002012 cites W2000349323 @default.
- W1897002012 cites W2001065358 @default.
- W1897002012 cites W2001173092 @default.
- W1897002012 cites W2002617338 @default.
- W1897002012 cites W2003683297 @default.
- W1897002012 cites W2006977912 @default.
- W1897002012 cites W2008675422 @default.
- W1897002012 cites W2008820074 @default.
- W1897002012 cites W2010728263 @default.
- W1897002012 cites W2014433643 @default.
- W1897002012 cites W2014555650 @default.
- W1897002012 cites W2015031752 @default.
- W1897002012 cites W2015344488 @default.
- W1897002012 cites W2015392958 @default.
- W1897002012 cites W2017967134 @default.
- W1897002012 cites W2023971274 @default.
- W1897002012 cites W2025651276 @default.
- W1897002012 cites W2025675798 @default.
- W1897002012 cites W2030119563 @default.
- W1897002012 cites W2033248531 @default.
- W1897002012 cites W2035649809 @default.
- W1897002012 cites W2038549365 @default.
- W1897002012 cites W2039795231 @default.
- W1897002012 cites W2052525658 @default.
- W1897002012 cites W2053970285 @default.
- W1897002012 cites W2056678512 @default.
- W1897002012 cites W2058827342 @default.
- W1897002012 cites W2061958603 @default.
- W1897002012 cites W2066378615 @default.
- W1897002012 cites W2066471622 @default.
- W1897002012 cites W2071851164 @default.
- W1897002012 cites W2073020765 @default.
- W1897002012 cites W2076748372 @default.
- W1897002012 cites W2081786869 @default.
- W1897002012 cites W2082334667 @default.
- W1897002012 cites W2082471811 @default.
- W1897002012 cites W2086444060 @default.
- W1897002012 cites W2096492418 @default.
- W1897002012 cites W2098814433 @default.
- W1897002012 cites W2103650142 @default.
- W1897002012 cites W2105220773 @default.
- W1897002012 cites W2106846696 @default.
- W1897002012 cites W2111543200 @default.
- W1897002012 cites W2111575740 @default.
- W1897002012 cites W2115560639 @default.
- W1897002012 cites W2118960787 @default.
- W1897002012 cites W2120215146 @default.
- W1897002012 cites W2123676911 @default.
- W1897002012 cites W2129338819 @default.
- W1897002012 cites W2130576870 @default.
- W1897002012 cites W2138454311 @default.
- W1897002012 cites W2139113799 @default.
- W1897002012 cites W2142552813 @default.
- W1897002012 cites W2142629585 @default.
- W1897002012 cites W2146558971 @default.
- W1897002012 cites W2148957569 @default.
- W1897002012 cites W2151862717 @default.
- W1897002012 cites W2153584576 @default.
- W1897002012 cites W2159086245 @default.
- W1897002012 cites W2161241353 @default.
- W1897002012 cites W2171949723 @default.
- W1897002012 cites W2172183886 @default.
- W1897002012 cites W3020926140 @default.
- W1897002012 cites W4238010870 @default.
- W1897002012 cites W4240289045 @default.
- W1897002012 cites W4243527941 @default.
- W1897002012 cites W4247896860 @default.
- W1897002012 cites W4252320237 @default.
- W1897002012 cites W5372497 @default.
- W1897002012 doi "https://doi.org/10.1089/ars.2013.5782" @default.
- W1897002012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4202924" @default.
- W1897002012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24328910" @default.
- W1897002012 hasPublicationYear "2014" @default.
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