FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897052165> ?p ?o ?g. }

• W1897052165 endingPage "5884" @default.
• W1897052165 startingPage "5876" @default.
• W1897052165 abstract "An elevation of β‐galactoside α2,6‐sialyltransferase (ST6Gal.I) enzyme activity and an increased α2,6‐sialylation of cell membranes are among the most prominent glycosylation changes associated with colon cancer; both modifications correlate with a worse prognosis. In our previous studies, we have frequently observed a discrepancy between the ST6Gal.I level within a colon cancer sample or cell line and the respective level of reactivity with the α2,6‐sialyl‐specific lectin from Sambucus nigra (SNA). In this study, we have investigated quantitatively the biosynthesis of the sialyl‐α2,6‐lactosaminyl epitope in two colon cancer cell types expressing the ST6Gal.I cDNA under the control of a constitutive promoter. By measuring the amount of ST6Gal.I mRNA using competitive RT‐PCR, the expression of α2,6‐sialylated lactosaminic structures with SNA and anti‐CDw75 Ig, and the presence of unsubstituted lactosaminic termini by Erythrina cristagalli lectin, we reached the following conclusions: (a) a high proportion of the cell surface lactosaminic termini remains unsubstituted, even in the presence of a very high ST6Gal.I activity. This proportion is strongly dependent on the cell type; (b) ST6Gal.I‐transfected colon cancer cells do not express the CDw75 epitope; (c) the level of ST6Gal.I enzyme activity only partially correlates with the mRNA level; (d) despite the control by a constitutive promoter, the ST6Gal.I mRNA is not constantly expressed over time; and (e) a very large portion of the enzyme molecules is secreted in the extracellular milieu. These results indicate that post‐transcriptional and post‐translational mechanisms play a pivotal role in the control of α2,6‐sialylation in colon cancer cells." @default.
• W1897052165 created "2016-06-24" @default.
• W1897052165 creator A5009615069 @default.
• W1897052165 creator A5033086164 @default.
• W1897052165 creator A5053375235 @default.
• W1897052165 creator A5072167771 @default.
• W1897052165 date "2001-11-15" @default.
• W1897052165 modified "2023-10-17" @default.
• W1897052165 title "Biosynthesis of the cancer-related sialyl-α2,6-lactosaminyl epitope in colon cancer cell lines expressing β-galactoside α2,6-sialyltransferase under a constitutive promoter" @default.
• W1897052165 cites W1500145492 @default.
• W1897052165 cites W1542808802 @default.
• W1897052165 cites W1554631282 @default.
• W1897052165 cites W1567197932 @default.
• W1897052165 cites W1582460637 @default.
• W1897052165 cites W1606167220 @default.
• W1897052165 cites W1666406333 @default.
• W1897052165 cites W171613518 @default.
• W1897052165 cites W1968882342 @default.
• W1897052165 cites W1973651395 @default.
• W1897052165 cites W1985645708 @default.
• W1897052165 cites W1986394299 @default.
• W1897052165 cites W1992943106 @default.
• W1897052165 cites W1997595270 @default.
• W1897052165 cites W1997812096 @default.
• W1897052165 cites W1998555144 @default.
• W1897052165 cites W1999479027 @default.
• W1897052165 cites W2003291723 @default.
• W1897052165 cites W2005119441 @default.
• W1897052165 cites W2014620417 @default.
• W1897052165 cites W2020057670 @default.
• W1897052165 cites W2036053694 @default.
• W1897052165 cites W2046723664 @default.
• W1897052165 cites W2048300048 @default.
• W1897052165 cites W2050266258 @default.
• W1897052165 cites W2122551579 @default.
• W1897052165 cites W2127227088 @default.
• W1897052165 cites W2127449110 @default.
• W1897052165 cites W2135624706 @default.
• W1897052165 cites W2163219838 @default.
• W1897052165 cites W2169335648 @default.
• W1897052165 cites W87311431 @default.
• W1897052165 doi "https://doi.org/10.1046/j.0014-2956.2001.02536.x" @default.
• W1897052165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11722575" @default.
• W1897052165 hasPublicationYear "2001" @default.
• W1897052165 type Work @default.
• W1897052165 sameAs 1897052165 @default.
• W1897052165 citedByCount "28" @default.
• W1897052165 countsByYear W18970521652012 @default.
• W1897052165 countsByYear W18970521652013 @default.
• W1897052165 countsByYear W18970521652015 @default.
• W1897052165 countsByYear W18970521652016 @default.
• W1897052165 countsByYear W18970521652020 @default.
• W1897052165 countsByYear W18970521652022 @default.
• W1897052165 countsByYear W18970521652023 @default.
• W1897052165 crossrefType "journal-article" @default.
• W1897052165 hasAuthorship W1897052165A5009615069 @default.
• W1897052165 hasAuthorship W1897052165A5033086164 @default.
• W1897052165 hasAuthorship W1897052165A5053375235 @default.
• W1897052165 hasAuthorship W1897052165A5072167771 @default.
• W1897052165 hasBestOaLocation W18970521651 @default.
• W1897052165 hasConcept C104317684 @default.
• W1897052165 hasConcept C108625454 @default.
• W1897052165 hasConcept C121608353 @default.
• W1897052165 hasConcept C1491633281 @default.
• W1897052165 hasConcept C153911025 @default.
• W1897052165 hasConcept C159654299 @default.
• W1897052165 hasConcept C181199279 @default.
• W1897052165 hasConcept C185592680 @default.
• W1897052165 hasConcept C187882448 @default.
• W1897052165 hasConcept C195616568 @default.
• W1897052165 hasConcept C203014093 @default.
• W1897052165 hasConcept C2777313579 @default.
• W1897052165 hasConcept C2778322149 @default.
• W1897052165 hasConcept C2780758401 @default.
• W1897052165 hasConcept C28406088 @default.
• W1897052165 hasConcept C526805850 @default.
• W1897052165 hasConcept C54355233 @default.
• W1897052165 hasConcept C55493867 @default.
• W1897052165 hasConcept C81885089 @default.
• W1897052165 hasConcept C86803240 @default.
• W1897052165 hasConceptScore W1897052165C104317684 @default.
• W1897052165 hasConceptScore W1897052165C108625454 @default.
• W1897052165 hasConceptScore W1897052165C121608353 @default.
• W1897052165 hasConceptScore W1897052165C1491633281 @default.
• W1897052165 hasConceptScore W1897052165C153911025 @default.
• W1897052165 hasConceptScore W1897052165C159654299 @default.
• W1897052165 hasConceptScore W1897052165C181199279 @default.
• W1897052165 hasConceptScore W1897052165C185592680 @default.
• W1897052165 hasConceptScore W1897052165C187882448 @default.
• W1897052165 hasConceptScore W1897052165C195616568 @default.
• W1897052165 hasConceptScore W1897052165C203014093 @default.
• W1897052165 hasConceptScore W1897052165C2777313579 @default.
• W1897052165 hasConceptScore W1897052165C2778322149 @default.
• W1897052165 hasConceptScore W1897052165C2780758401 @default.
• W1897052165 hasConceptScore W1897052165C28406088 @default.
• W1897052165 hasConceptScore W1897052165C526805850 @default.
• W1897052165 hasConceptScore W1897052165C54355233 @default.
• W1897052165 hasConceptScore W1897052165C55493867 @default.

• next