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• W189719753 abstract "Genetic, or genomic, instability refers to a series of observed spontaneous genetic changes occurring at an accelerated rate in cell populations derived from the same ancestral precursor. This is far from a new finding, but is one that has increasingly gained more attention in the last decade due to its plausible role(s) in tumorigenesis. The majority of genetic alterations contributing to the malignant transformation are seen in growth regulatory genes, and in genes involved in cell cycle progression and arrest. Genomic instability may present itself through alterations in the length of short repeat stretches of coding and non-coding DNA, resulting in microsatellite instability. Tumors with such profiles are referred to as exhibiting a mutator phenotype, which is largely a consequence of inactivating mutations in DNA damage repair genes. Genomic instability may also, and most commonly, results from gross chromosomal changes, such as translocations or amplifications, which lead to chromosomal instability. Telomere length and telomerase activity, important in maintaining chromosomal structure and in regulating a normal cell's lifespan, have been shown to have a function in both suppressing and facilitating malignant transformation. In addition to such direct sequence and structural changes, gene silencing through the hypermethylation of promoter regions, or increased gene expression through the hypomethylation of such regions, together, form an alternative, epigenetic mechanism leading to instability. Emerging evidence also suggests that dietary and environmental agents can further modulate the contribution of genetic instability to tumorigenesis. Currently, there is still much debate over the distinct classes of genomic instability and their specific roles in the initiation of tumor formation, as well as in the progressive transition to a cancerous state. This review examines the various molecular mechanisms that result in this genomic instability and the potential contribution of the latter to human carcinogenesis." @default.
• W189719753 created "2016-06-24" @default.
• W189719753 creator A5015061133 @default.
• W189719753 creator A5057092796 @default.
• W189719753 date "2006-01-26" @default.
• W189719753 modified "2023-09-24" @default.
• W189719753 title "Genetic instability in human tumors" @default.
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• W189719753 cites W1484293540 @default.
• W189719753 cites W1522569372 @default.
• W189719753 cites W1541050437 @default.
• W189719753 cites W1544851750 @default.
• W189719753 cites W1552528612 @default.
• W189719753 cites W1657157395 @default.
• W189719753 cites W1968407767 @default.
• W189719753 cites W1971366079 @default.
• W189719753 cites W1974747095 @default.
• W189719753 cites W1978419388 @default.
• W189719753 cites W1978626016 @default.
• W189719753 cites W1982310288 @default.
• W189719753 cites W1982497017 @default.
• W189719753 cites W1984542357 @default.
• W189719753 cites W1984825396 @default.
• W189719753 cites W1990381590 @default.
• W189719753 cites W1994713924 @default.
• W189719753 cites W1997493715 @default.
• W189719753 cites W1998777735 @default.
• W189719753 cites W1999628809 @default.
• W189719753 cites W2000170100 @default.
• W189719753 cites W2007366502 @default.
• W189719753 cites W2012071848 @default.
• W189719753 cites W2013756789 @default.
• W189719753 cites W2023194603 @default.
• W189719753 cites W2023426690 @default.
• W189719753 cites W2024533570 @default.
• W189719753 cites W2025448669 @default.
• W189719753 cites W2026856852 @default.
• W189719753 cites W2026895762 @default.
• W189719753 cites W2033166156 @default.
• W189719753 cites W2034269086 @default.
• W189719753 cites W2036103078 @default.
• W189719753 cites W2039444662 @default.
• W189719753 cites W2040157600 @default.
• W189719753 cites W2043033879 @default.
• W189719753 cites W2046509449 @default.
• W189719753 cites W2052665087 @default.
• W189719753 cites W2058963557 @default.
• W189719753 cites W2059355615 @default.
• W189719753 cites W2060739426 @default.
• W189719753 cites W2061891352 @default.
• W189719753 cites W2062421371 @default.
• W189719753 cites W2065423665 @default.
• W189719753 cites W2073367384 @default.
• W189719753 cites W2075642823 @default.
• W189719753 cites W2080308138 @default.
• W189719753 cites W2083275000 @default.
• W189719753 cites W2083860773 @default.
• W189719753 cites W2084913211 @default.
• W189719753 cites W2085046107 @default.
• W189719753 cites W2085745662 @default.
• W189719753 cites W2085843470 @default.
• W189719753 cites W2090194040 @default.
• W189719753 cites W2091658754 @default.
• W189719753 cites W2095301528 @default.
• W189719753 cites W2096136751 @default.
• W189719753 cites W2100143432 @default.
• W189719753 cites W2100550233 @default.
• W189719753 cites W2108482850 @default.
• W189719753 cites W2112481194 @default.
• W189719753 cites W2119212185 @default.
• W189719753 cites W2121417064 @default.
• W189719753 cites W2121585544 @default.
• W189719753 cites W2127016346 @default.
• W189719753 cites W2127884528 @default.
• W189719753 cites W2131952001 @default.
• W189719753 cites W2135718122 @default.
• W189719753 cites W2136492640 @default.
• W189719753 cites W2139443220 @default.
• W189719753 cites W2143138913 @default.
• W189719753 cites W2143227642 @default.
• W189719753 cites W2143828280 @default.
• W189719753 cites W2144438106 @default.
• W189719753 cites W2144536107 @default.
• W189719753 cites W2149403662 @default.
• W189719753 cites W2150162153 @default.
• W189719753 cites W2150914815 @default.
• W189719753 cites W2154181923 @default.
• W189719753 cites W2163330492 @default.
• W189719753 cites W2171416485 @default.
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• W189719753 doi "https://doi.org/10.1007/3-7643-7378-4_13" @default.
• W189719753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16383024" @default.
• W189719753 hasPublicationYear "2006" @default.
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