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- W1897205303 abstract "Abstract Context—Although genome-wide imbalances have been characterized in conventional adenoid cystic carcinoma, other than p53 mutational status, the molecular profile of adenoid cystic carcinoma with high-grade transformation has not been explored. Objective—To evaluate progressive genetic alterations in adenoid cystic carcinoma with high-grade transformation using array comparative genomic hybridization. Design—Five adenoid cystic carcinomas with high-grade transformation (4 primary tumors and 1 paired metastasis) were selected and characterized at the DNA level by array comparative genomic hybridization on formalin-fixed paraffin-embedded tissue. Select alterations were validated by fluorescence in situ hybridization. Results—Chromosomal gains were mostly confined to the areas of high-grade transformation while losses were seen only in the conventional areas. Chromosomal regions with significant gains included 8q24, 17q11.2-q12, 17q23, and 15q11-13. Regions that showed the significant losses include..." @default.
- W1897205303 created "2016-06-24" @default.
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- W1897205303 date "2011-01-01" @default.
- W1897205303 modified "2023-09-23" @default.
- W1897205303 title "Progressive Genetic Alterations of Adenoid Cystic Carcinoma With High-Grade Transformation" @default.
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- W1897205303 doi "https://doi.org/10.1043/2010-0048-oar.1" @default.
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