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- W1897268175 abstract "Previously known 3-(2-pyridyl)amino-2-cyanо and 3-(2-pyridyl)amino-2-acetylacrylamides have been syn-thesized by three-component interaction of 2-aminopyridine, cyanacetic acid amides or acetoacetic acid amides and ethylic ester of orthoformic acid. Their physical and chemical properties have been studied. The structure of compounds has been confirmed by spectroscopy. According the IR and NMR Н1 spectra obtained compounds have the enamine structure with chelate type intermolecular hydrogen bond. Biological trials have revealed that 3-(2-pyridyl)amino-2-cyanоacrylate acid allilamid have anticonvulsant activity and of 3 (2-pyridyl) amino-2-acetylacrylate acid 2-chloroanilide have antiinflammatory activity. Primidone (hexamidine) and acetylsalicylic acid (aspirin) have been used as reference substances. It is possible to obtain enamines with different chemical structures. Further search of potentially biologically active compounds in this series is promising." @default.
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- W1897268175 date "2012-01-01" @default.
- W1897268175 modified "2023-09-28" @default.
- W1897268175 title "Синтез, свойства и биологическая активность 3-(2-пиридил)амино-2-циано – и 3-(2-пиридил)амино- 2-ацетилакриламидов" @default.
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