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• W1897310892 endingPage "e0004148" @default.
• W1897310892 startingPage "e0004148" @default.
• W1897310892 abstract "Chronic Chagas cardiomyopathy caused by Trypanosoma cruzi is the result of a pathologic process starting during the acute phase of parasite infection. Among different factors, the specific recognition of glycan structures by glycan-binding proteins from the parasite or from the mammalian host cells may play a critical role in the evolution of the infection.Here we investigated the contribution of galectin-1 (Gal-1), an endogenous glycan-binding protein abundantly expressed in human and mouse heart, to the pathophysiology of T. cruzi infection, particularly in the context of cardiac pathology. We found that exposure of HL-1 cardiac cells to Gal-1 reduced the percentage of infection by two different T. cruzi strains, Tulahuén (TcVI) and Brazil (TcI). In addition, Gal-1 prevented exposure of phosphatidylserine and early events in the apoptotic program by parasite infection on HL-1 cells. These effects were not mediated by direct interaction with the parasite surface, suggesting that Gal-1 may act through binding to host cells. Moreover, we also observed that T. cruzi infection altered the glycophenotype of cardiac cells, reducing binding of exogenous Gal-1 to the cell surface. Consistent with these data, Gal-1 deficient (Lgals1-/-) mice showed increased parasitemia, reduced signs of inflammation in heart and skeletal muscle tissues, and lower survival rates as compared to wild-type (WT) mice in response to intraperitoneal infection with T. cruzi Tulahuén strain.Our results indicate that Gal-1 modulates T. cruzi infection of cardiac cells, highlighting the relevance of galectins and their ligands as regulators of host-parasite interactions." @default.
• W1897310892 created "2016-06-24" @default.
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• W1897310892 date "2015-10-09" @default.
• W1897310892 modified "2023-10-06" @default.
• W1897310892 title "Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells" @default.
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• W1897310892 doi "https://doi.org/10.1371/journal.pntd.0004148" @default.
• W1897310892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4599936" @default.
• W1897310892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26451839" @default.
• W1897310892 hasPublicationYear "2015" @default.
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