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• W1897425192 abstract "Research Article20 December 1988free access The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription. E. deBoer E. deBoer Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author M. Antoniou M. Antoniou Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author V. Mignotte V. Mignotte Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author L. Wall L. Wall Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author F. Grosveld F. Grosveld Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author E. deBoer E. deBoer Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author M. Antoniou M. Antoniou Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author V. Mignotte V. Mignotte Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author L. Wall L. Wall Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author F. Grosveld F. Grosveld Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. Search for more papers by this author Author Information E. deBoer1, M. Antoniou1, V. Mignotte1, L. Wall1 and F. Grosveld1 1Laboratory of Gene Structure and Expression, National Institute for Medical Research, UK. The EMBO Journal (1988)7:4203-4212https://doi.org/10.1002/j.1460-2075.1988.tb03317.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have shown that the promoter of the human beta-globin gene contains three regions in addition to the known CAC, CAAT and TATA box regions that are important for the induction of transcription in erythroid cells. By using DNaseI footprinting and gel mobility shift assays we were able to show that two of these regions bind the erythroid specific nuclear factor NF-E1 (and ubiquitous factors). The third region binds a ubiquitous CAAT-box factor (CP1). Deletion experiments suggest that only the combination of NF-E1 and CP1 binding sites, but not each of the sites alone, are capable of mediating the induction of transcription of a minimal (CAC, CAAT, TATA box) beta-globin promoter in mouse erythroleukaemia (MEL) cells. Previous ArticleNext Article Volume 7Issue 131 December 1988In this issue RelatedDetailsLoading ..." @default.
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• W1897425192 title "The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription." @default.
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• W1897425192 doi "https://doi.org/10.1002/j.1460-2075.1988.tb03317.x" @default.
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