Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897568757> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1897568757 endingPage "1875" @default.
- W1897568757 startingPage "1868" @default.
- W1897568757 abstract "Abstract The IgE/Fc epsilonRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by Fc epsilonRI+ non-B, non-T (NBNT) cells. To formally evaluate the role of IgE/Fc epsilonRI signaling in the host response to helminths we studied Schistosoma mansoni infection in Fc epsilonRI knockout (KO) mice. Infected wild-type (wt) and KO animals showed comparable adult worm and tissue egg burdens, arguing against a role for Fc epsilonRI interactions in host resistance. Significantly, NBNT cells from infected KO, in contrast to wt animals, did not secrete IL-4 when stimulated with anti-IgE Ab or soluble parasite Ag. Nevertheless, serum IgE levels and Th2 cytokine production profiles were comparable in both strains of mice, demonstrating that the Ag-dependent stimulation of IL-4 secretion by NBNT cells is not essential for helminth-induced Th2 differentiation. However, when stimulated with low Ag doses, splenocytes from infected Fc epsilonRI-deficient mice produced less IL-4 in vitro than similar cultures from infected wt animals, an effect attributable to their defective NBNT cell function. Moreover, infected KO mice showed enhanced egg granuloma formation and hepatic fibrosis, revealing that the IgE/Fc epsilonRI interaction, while not essential for Th2 response development or resistance to primary infection, plays a significant role in down-regulating host pathology." @default.
- W1897568757 created "2016-06-24" @default.
- W1897568757 creator A5001525881 @default.
- W1897568757 creator A5007182284 @default.
- W1897568757 creator A5016487212 @default.
- W1897568757 creator A5017780794 @default.
- W1897568757 creator A5018293071 @default.
- W1897568757 creator A5033997225 @default.
- W1897568757 creator A5058339126 @default.
- W1897568757 creator A5066367346 @default.
- W1897568757 creator A5073562393 @default.
- W1897568757 creator A5086600642 @default.
- W1897568757 date "1997-08-15" @default.
- W1897568757 modified "2023-10-10" @default.
- W1897568757 title "Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology." @default.
- W1897568757 doi "https://doi.org/10.4049/jimmunol.159.4.1868" @default.
- W1897568757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9257851" @default.
- W1897568757 hasPublicationYear "1997" @default.
- W1897568757 type Work @default.
- W1897568757 sameAs 1897568757 @default.
- W1897568757 citedByCount "53" @default.
- W1897568757 countsByYear W18975687572012 @default.
- W1897568757 countsByYear W18975687572013 @default.
- W1897568757 countsByYear W18975687572014 @default.
- W1897568757 countsByYear W18975687572015 @default.
- W1897568757 countsByYear W18975687572016 @default.
- W1897568757 countsByYear W18975687572018 @default.
- W1897568757 countsByYear W18975687572019 @default.
- W1897568757 countsByYear W18975687572022 @default.
- W1897568757 countsByYear W18975687572023 @default.
- W1897568757 crossrefType "journal-article" @default.
- W1897568757 hasAuthorship W1897568757A5001525881 @default.
- W1897568757 hasAuthorship W1897568757A5007182284 @default.
- W1897568757 hasAuthorship W1897568757A5016487212 @default.
- W1897568757 hasAuthorship W1897568757A5017780794 @default.
- W1897568757 hasAuthorship W1897568757A5018293071 @default.
- W1897568757 hasAuthorship W1897568757A5033997225 @default.
- W1897568757 hasAuthorship W1897568757A5058339126 @default.
- W1897568757 hasAuthorship W1897568757A5066367346 @default.
- W1897568757 hasAuthorship W1897568757A5073562393 @default.
- W1897568757 hasAuthorship W1897568757A5086600642 @default.
- W1897568757 hasBestOaLocation W18975687571 @default.
- W1897568757 hasConcept C134018914 @default.
- W1897568757 hasConcept C141105273 @default.
- W1897568757 hasConcept C159654299 @default.
- W1897568757 hasConcept C165901193 @default.
- W1897568757 hasConcept C191732599 @default.
- W1897568757 hasConcept C203014093 @default.
- W1897568757 hasConcept C2776225656 @default.
- W1897568757 hasConcept C2776863245 @default.
- W1897568757 hasConcept C2778491710 @default.
- W1897568757 hasConcept C2778690821 @default.
- W1897568757 hasConcept C49039625 @default.
- W1897568757 hasConcept C51785407 @default.
- W1897568757 hasConcept C86803240 @default.
- W1897568757 hasConceptScore W1897568757C134018914 @default.
- W1897568757 hasConceptScore W1897568757C141105273 @default.
- W1897568757 hasConceptScore W1897568757C159654299 @default.
- W1897568757 hasConceptScore W1897568757C165901193 @default.
- W1897568757 hasConceptScore W1897568757C191732599 @default.
- W1897568757 hasConceptScore W1897568757C203014093 @default.
- W1897568757 hasConceptScore W1897568757C2776225656 @default.
- W1897568757 hasConceptScore W1897568757C2776863245 @default.
- W1897568757 hasConceptScore W1897568757C2778491710 @default.
- W1897568757 hasConceptScore W1897568757C2778690821 @default.
- W1897568757 hasConceptScore W1897568757C49039625 @default.
- W1897568757 hasConceptScore W1897568757C51785407 @default.
- W1897568757 hasConceptScore W1897568757C86803240 @default.
- W1897568757 hasIssue "4" @default.
- W1897568757 hasLocation W18975687571 @default.
- W1897568757 hasLocation W18975687572 @default.
- W1897568757 hasOpenAccess W1897568757 @default.
- W1897568757 hasPrimaryLocation W18975687571 @default.
- W1897568757 hasRelatedWork W140483571 @default.
- W1897568757 hasRelatedWork W1759882342 @default.
- W1897568757 hasRelatedWork W1985209512 @default.
- W1897568757 hasRelatedWork W1991485358 @default.
- W1897568757 hasRelatedWork W2018086734 @default.
- W1897568757 hasRelatedWork W202973276 @default.
- W1897568757 hasRelatedWork W2099013529 @default.
- W1897568757 hasRelatedWork W2149749568 @default.
- W1897568757 hasRelatedWork W2157651756 @default.
- W1897568757 hasRelatedWork W2413773413 @default.
- W1897568757 hasVolume "159" @default.
- W1897568757 isParatext "false" @default.
- W1897568757 isRetracted "false" @default.
- W1897568757 magId "1897568757" @default.
- W1897568757 workType "article" @default.