Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897584080> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1897584080 endingPage "56" @default.
- W1897584080 startingPage "249" @default.
- W1897584080 abstract "The purpose of this study was to investigate the kinetics of urinary excretion of heroin and its metabolites in human subjects. Heroin and its metabolites were determined with gas-liquid chromatography. Two studies were conducted, each using 10 subjects. After i.v. administration of heroin HC1, 10 mg/70 kg, urine was collected every 8 hours and ad libitum for 1 week in the first study and every 2 hours in the first 8 hours and then at less frequent intervals for 24 hours in the second study. Heroin, 6-acetylmorphine, morphine, the sum of conjugates (morphine plus 6-acetylmorphine) and total normorphine were determined in the first 24-hour urine and accounted for 0.5, 1.5, 7.2, 52 and 4%, respectively, of the administered dose. Conjugated morphine could be detected in the urine 96 hours after drug administration. Eighty-eight percent of the free morphine and 84% of the total morphine found in the urine were excreted in the first 8 hours. The half-lives of urinary excretion of free morphine, 6-acetylmorphine, the sum of conjugates (morphine plus 6-acetylmorphine) and total normorphine were 1.28, 1.31, 2.76 and 2.72 hours, respectively. It was concluded that heroin in the body was rapidly metabolized and its metabolites were rapidly excreted in the urine." @default.
- W1897584080 created "2016-06-24" @default.
- W1897584080 creator A5004772264 @default.
- W1897584080 creator A5013056698 @default.
- W1897584080 creator A5083705224 @default.
- W1897584080 date "1976-02-01" @default.
- W1897584080 modified "2023-09-23" @default.
- W1897584080 title "Urinary excretion of heroin and its metabolites in man." @default.
- W1897584080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1255475" @default.
- W1897584080 hasPublicationYear "1976" @default.
- W1897584080 type Work @default.
- W1897584080 sameAs 1897584080 @default.
- W1897584080 citedByCount "18" @default.
- W1897584080 countsByYear W18975840802012 @default.
- W1897584080 countsByYear W18975840802013 @default.
- W1897584080 countsByYear W18975840802019 @default.
- W1897584080 countsByYear W18975840802022 @default.
- W1897584080 crossrefType "journal-article" @default.
- W1897584080 hasAuthorship W1897584080A5004772264 @default.
- W1897584080 hasAuthorship W1897584080A5013056698 @default.
- W1897584080 hasAuthorship W1897584080A5083705224 @default.
- W1897584080 hasConcept C10146269 @default.
- W1897584080 hasConcept C126322002 @default.
- W1897584080 hasConcept C185592680 @default.
- W1897584080 hasConcept C2776768635 @default.
- W1897584080 hasConcept C2777389121 @default.
- W1897584080 hasConcept C2777477808 @default.
- W1897584080 hasConcept C2778903686 @default.
- W1897584080 hasConcept C2780026642 @default.
- W1897584080 hasConcept C2780035454 @default.
- W1897584080 hasConcept C6557445 @default.
- W1897584080 hasConcept C71924100 @default.
- W1897584080 hasConcept C77411442 @default.
- W1897584080 hasConcept C86803240 @default.
- W1897584080 hasConcept C98274493 @default.
- W1897584080 hasConceptScore W1897584080C10146269 @default.
- W1897584080 hasConceptScore W1897584080C126322002 @default.
- W1897584080 hasConceptScore W1897584080C185592680 @default.
- W1897584080 hasConceptScore W1897584080C2776768635 @default.
- W1897584080 hasConceptScore W1897584080C2777389121 @default.
- W1897584080 hasConceptScore W1897584080C2777477808 @default.
- W1897584080 hasConceptScore W1897584080C2778903686 @default.
- W1897584080 hasConceptScore W1897584080C2780026642 @default.
- W1897584080 hasConceptScore W1897584080C2780035454 @default.
- W1897584080 hasConceptScore W1897584080C6557445 @default.
- W1897584080 hasConceptScore W1897584080C71924100 @default.
- W1897584080 hasConceptScore W1897584080C77411442 @default.
- W1897584080 hasConceptScore W1897584080C86803240 @default.
- W1897584080 hasConceptScore W1897584080C98274493 @default.
- W1897584080 hasIssue "2" @default.
- W1897584080 hasLocation W18975840801 @default.
- W1897584080 hasOpenAccess W1897584080 @default.
- W1897584080 hasPrimaryLocation W18975840801 @default.
- W1897584080 hasRelatedWork W1570030466 @default.
- W1897584080 hasRelatedWork W188976182 @default.
- W1897584080 hasRelatedWork W1897584080 @default.
- W1897584080 hasRelatedWork W1992359629 @default.
- W1897584080 hasRelatedWork W2006804590 @default.
- W1897584080 hasRelatedWork W2074941443 @default.
- W1897584080 hasRelatedWork W2154488041 @default.
- W1897584080 hasRelatedWork W2390193836 @default.
- W1897584080 hasRelatedWork W2432726492 @default.
- W1897584080 hasRelatedWork W2911895287 @default.
- W1897584080 hasVolume "196" @default.
- W1897584080 isParatext "false" @default.
- W1897584080 isRetracted "false" @default.
- W1897584080 magId "1897584080" @default.
- W1897584080 workType "article" @default.