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- W1897617897 abstract "Purpose To evaluate late gadolinium‐enhanced (LGE) assessment of infarct size, a comparison with manganese‐enhanced magnetic resonance imaging (MEMRI), and histology was performed in a permanent infarction model in the mouse at the acute and chronic stage. Materials and Methods In a paired fashion at the acute and chronic stage after infarction (3–4 days and 21 days, respectively), LGE and MEMRI was performed using a self‐gated fast low flip angle shot (FLASH). Infarct size was evaluated as the enhanced area relative to the complete myocardial wall area in a mid‐ventricular slice. Paired comparisons were made between contrast agents and between timepoints, as well as to histology. Results At the acute stage, LGE delineated a larger infarct size as compared to both MEMRI and histology. Infarct size from LGE decreased from the acute to chronic stage, a temporal development not seen with MEMRI. At the chronic stage, no significant differences in infarct size were found between the methods. Conclusion This study indicates an overenhancement of infarct size when using LGE, supported by an initial overestimation at the acute stage and a temporal decrease in infarct size from the acute to chronic stage, as compared to infarct size from MEMRI. J. Magn. Reson. Imaging 2013;38:1388–1394. © 2013 Wiley Periodicals, Inc." @default.
- W1897617897 created "2016-06-24" @default.
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- W1897617897 date "2013-04-04" @default.
- W1897617897 modified "2023-10-17" @default.
- W1897617897 title "Late gadolinium enhancement in the assessment of the infarcted mouse heart: A longitudinal comparison with manganese-enhanced MRI" @default.
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- W1897617897 doi "https://doi.org/10.1002/jmri.24127" @default.
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