Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897750732> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1897750732 endingPage "72" @default.
- W1897750732 startingPage "365" @default.
- W1897750732 abstract "Besides its role as a barrier against potential pathogens, intestinal flora is presumed to protect the host by priming the immunological defense mechanisms. In this respect, the influence of intestinal flora on macrophage precursors was examined, and its modulating effect was compared on LPS-induced cytokine production by macrophages derived from bone marrow and spleen precursors (BMDM and SDM respectively). The regulation of IL-1, IL-6, TNF-alpha and IL-12 production in macrophages from germ-free and from three groups of flora-associated mice, conventional, conventionalized and E. coli-mono-associated mice, was investigated. The whole flora inhibited IL-1, TNF-alpha and IL-12 secretion by BMDM, whereas it had a stimulatory effect on IL-12 secretion by SDM. Implantation of E. coli alone enhanced cytokine secretion by BMDM but had a more limited effect than whole flora on SDM, enhancing only TNF-alpha and IL-12 secretion. Study of expression of mRNA showed a correlation with protein secretion for IL-6 but not for TNF-alpha and IL-1. IL-12 enhancement in BMDM seemed to be dependent on regulation of p35 mRNA expression while it was correlated to increased p40 mRNA expression in SDM. The results demonstrated that intestinal flora modulated bone marrow and spleen macrophage cytokine production in a differential manner and suggested a role for bacteria other than E. coli among the whole flora. The contrasting effects exerted by the intestinal flora on bone marrow and spleen precursors are an interesting observation in view of the different functions of these organs in immunity. The finding that intestinal flora enhanced IL-12 production in spleen is also potentially important since this cytokine is implicated in the determination of the relative levels of Th1 and Th2 responses and plays a pivotal role in host defense against intracellular microorganisms." @default.
- W1897750732 created "2016-06-24" @default.
- W1897750732 creator A5011287991 @default.
- W1897750732 creator A5020197270 @default.
- W1897750732 creator A5060232276 @default.
- W1897750732 creator A5083192227 @default.
- W1897750732 creator A5083438463 @default.
- W1897750732 creator A5090783343 @default.
- W1897750732 creator A5076527823 @default.
- W1897750732 date "1999-09-01" @default.
- W1897750732 modified "2023-10-12" @default.
- W1897750732 title "The intestinal microflora regulates cytokine production positively in spleen-derived macrophages but negatively in bone marrow-derived macrophages." @default.
- W1897750732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477393" @default.
- W1897750732 hasPublicationYear "1999" @default.
- W1897750732 type Work @default.
- W1897750732 sameAs 1897750732 @default.
- W1897750732 citedByCount "8" @default.
- W1897750732 countsByYear W18977507322013 @default.
- W1897750732 countsByYear W18977507322015 @default.
- W1897750732 countsByYear W18977507322021 @default.
- W1897750732 crossrefType "journal-article" @default.
- W1897750732 hasAuthorship W1897750732A5011287991 @default.
- W1897750732 hasAuthorship W1897750732A5020197270 @default.
- W1897750732 hasAuthorship W1897750732A5060232276 @default.
- W1897750732 hasAuthorship W1897750732A5076527823 @default.
- W1897750732 hasAuthorship W1897750732A5083192227 @default.
- W1897750732 hasAuthorship W1897750732A5083438463 @default.
- W1897750732 hasAuthorship W1897750732A5090783343 @default.
- W1897750732 hasConcept C100701293 @default.
- W1897750732 hasConcept C134018914 @default.
- W1897750732 hasConcept C17991360 @default.
- W1897750732 hasConcept C187316574 @default.
- W1897750732 hasConcept C202751555 @default.
- W1897750732 hasConcept C203014093 @default.
- W1897750732 hasConcept C2777234453 @default.
- W1897750732 hasConcept C2778690821 @default.
- W1897750732 hasConcept C2779244956 @default.
- W1897750732 hasConcept C2780007613 @default.
- W1897750732 hasConcept C2780931953 @default.
- W1897750732 hasConcept C49039625 @default.
- W1897750732 hasConcept C523546767 @default.
- W1897750732 hasConcept C54355233 @default.
- W1897750732 hasConcept C55493867 @default.
- W1897750732 hasConcept C59822182 @default.
- W1897750732 hasConcept C81444415 @default.
- W1897750732 hasConcept C86803240 @default.
- W1897750732 hasConcept C89423630 @default.
- W1897750732 hasConceptScore W1897750732C100701293 @default.
- W1897750732 hasConceptScore W1897750732C134018914 @default.
- W1897750732 hasConceptScore W1897750732C17991360 @default.
- W1897750732 hasConceptScore W1897750732C187316574 @default.
- W1897750732 hasConceptScore W1897750732C202751555 @default.
- W1897750732 hasConceptScore W1897750732C203014093 @default.
- W1897750732 hasConceptScore W1897750732C2777234453 @default.
- W1897750732 hasConceptScore W1897750732C2778690821 @default.
- W1897750732 hasConceptScore W1897750732C2779244956 @default.
- W1897750732 hasConceptScore W1897750732C2780007613 @default.
- W1897750732 hasConceptScore W1897750732C2780931953 @default.
- W1897750732 hasConceptScore W1897750732C49039625 @default.
- W1897750732 hasConceptScore W1897750732C523546767 @default.
- W1897750732 hasConceptScore W1897750732C54355233 @default.
- W1897750732 hasConceptScore W1897750732C55493867 @default.
- W1897750732 hasConceptScore W1897750732C59822182 @default.
- W1897750732 hasConceptScore W1897750732C81444415 @default.
- W1897750732 hasConceptScore W1897750732C86803240 @default.
- W1897750732 hasConceptScore W1897750732C89423630 @default.
- W1897750732 hasIssue "3" @default.
- W1897750732 hasLocation W18977507321 @default.
- W1897750732 hasOpenAccess W1897750732 @default.
- W1897750732 hasPrimaryLocation W18977507321 @default.
- W1897750732 hasRelatedWork W1897750732 @default.
- W1897750732 hasRelatedWork W1914832232 @default.
- W1897750732 hasRelatedWork W1968122107 @default.
- W1897750732 hasRelatedWork W2000670653 @default.
- W1897750732 hasRelatedWork W2014765417 @default.
- W1897750732 hasRelatedWork W2049022179 @default.
- W1897750732 hasRelatedWork W2062519020 @default.
- W1897750732 hasRelatedWork W2062816540 @default.
- W1897750732 hasRelatedWork W2328473951 @default.
- W1897750732 hasRelatedWork W2337839168 @default.
- W1897750732 hasVolume "10" @default.
- W1897750732 isParatext "false" @default.
- W1897750732 isRetracted "false" @default.
- W1897750732 magId "1897750732" @default.
- W1897750732 workType "article" @default.