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• W1897788786 abstract "Abdominal aortic aneurysm (AAA) is a progressive inflammatory disease of the artery walls. Immune cells, including B lymphocytes, are implicated in the pathogenesis of AAA through interconnected mechanisms. Many studies have shown that compared with normal abdominal aortic tissue, the amount of B lymphocytes that infiltrate the adventitia of AAAs was significantly higher. Activated B lymphocytes promote AAA by producing immunoglobulins, cytokines, and matrix metalloproteinases (MMPs), resulting in the activation of macrophages, mast cells (MCs) and complement pathways. Finally, all of these factors lead to the degradation of collagen and matrix proteins and to aortic wall remodeling, which are hallmarks of AAA. However, few studies focus on the relative function of B cells, and their precise mechanisms in AAA remain unclear. Thus, we summarize the current knowledge on the role of B cells in AAA and offer recommendations for further investigation of preventing the progression of AAA." @default.
• W1897788786 created "2016-06-24" @default.
• W1897788786 creator A5056969457 @default.
• W1897788786 creator A5057973270 @default.
• W1897788786 date "2015-09-01" @default.
• W1897788786 modified "2023-10-03" @default.
• W1897788786 title "B lymphocytes in abdominal aortic aneurysms" @default.
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• W1897788786 doi "https://doi.org/10.1016/j.atherosclerosis.2015.07.036" @default.
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