Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897943175> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1897943175 abstract "Collections of individual case safety reports are the main resource for early discovery of unknown adverse reactions to drugs once they have been introduced to the general public. The data sets involved are complex and based on voluntary submission of reports, but contain pieces of very important information. The aim of this thesis is to propose computationally feasible statistical methods for large-scale knowledge discovery in these data sets. The main contributions are a duplicate detection method that can reliably identify pairs of unexpectedly similar reports and a new measure for highlighting suspected drug-drug interaction. Specifically, we extend the hit-miss model for database record matching with a hit-miss mixture model for scoring numerical record fields and a new method to compensate for strong record field correlations. The extended hit-miss model is implemented for the WHO database and demonstrated to be useful in real world duplicate detection, despite the noisy and incomplete information on individual case safety reports. The Information Component measure of disproportionality has been in routine use since 1998 to screen the WHO database for excessive adverse drug reaction reporting rates. Here, it is further refined. We introduce improved credibility intervals for rare events, post-stratification adjustment for suspected confounders and an extension to higher order associations that allows for simple but robust screening for potential risk factors. A new approach to identifying reporting patterns indicative of drug-drug interaction is also proposed. Finally, we describe how imprecision estimates specific to each prediction of a Bayes classifier may be obtained with the Bayesian bootstrap. Such case-based imprecision estimates allow for better prediction when different types of errors have different associated loss, with a possible application in combining quantitative and clinical filters to highlight drug-ADR pairs for clinical review." @default.
- W1897943175 created "2016-06-24" @default.
- W1897943175 creator A5002909029 @default.
- W1897943175 creator A5022900127 @default.
- W1897943175 creator A5033355840 @default.
- W1897943175 creator A5079757543 @default.
- W1897943175 date "2007-01-01" @default.
- W1897943175 modified "2023-09-27" @default.
- W1897943175 title "Adjustment for potential confounders in adverse drug reaction surveillance" @default.
- W1897943175 hasPublicationYear "2007" @default.
- W1897943175 type Work @default.
- W1897943175 sameAs 1897943175 @default.
- W1897943175 citedByCount "1" @default.
- W1897943175 crossrefType "journal-article" @default.
- W1897943175 hasAuthorship W1897943175A5002909029 @default.
- W1897943175 hasAuthorship W1897943175A5022900127 @default.
- W1897943175 hasAuthorship W1897943175A5033355840 @default.
- W1897943175 hasAuthorship W1897943175A5079757543 @default.
- W1897943175 hasConcept C105795698 @default.
- W1897943175 hasConcept C107673813 @default.
- W1897943175 hasConcept C119857082 @default.
- W1897943175 hasConcept C124101348 @default.
- W1897943175 hasConcept C154945302 @default.
- W1897943175 hasConcept C165064840 @default.
- W1897943175 hasConcept C17744445 @default.
- W1897943175 hasConcept C199539241 @default.
- W1897943175 hasConcept C207201462 @default.
- W1897943175 hasConcept C2780224610 @default.
- W1897943175 hasConcept C33923547 @default.
- W1897943175 hasConcept C41008148 @default.
- W1897943175 hasConcept C95623464 @default.
- W1897943175 hasConceptScore W1897943175C105795698 @default.
- W1897943175 hasConceptScore W1897943175C107673813 @default.
- W1897943175 hasConceptScore W1897943175C119857082 @default.
- W1897943175 hasConceptScore W1897943175C124101348 @default.
- W1897943175 hasConceptScore W1897943175C154945302 @default.
- W1897943175 hasConceptScore W1897943175C165064840 @default.
- W1897943175 hasConceptScore W1897943175C17744445 @default.
- W1897943175 hasConceptScore W1897943175C199539241 @default.
- W1897943175 hasConceptScore W1897943175C207201462 @default.
- W1897943175 hasConceptScore W1897943175C2780224610 @default.
- W1897943175 hasConceptScore W1897943175C33923547 @default.
- W1897943175 hasConceptScore W1897943175C41008148 @default.
- W1897943175 hasConceptScore W1897943175C95623464 @default.
- W1897943175 hasLocation W18979431751 @default.
- W1897943175 hasOpenAccess W1897943175 @default.
- W1897943175 hasPrimaryLocation W18979431751 @default.
- W1897943175 hasRelatedWork W1165431436 @default.
- W1897943175 hasRelatedWork W2017322012 @default.
- W1897943175 hasRelatedWork W2121354097 @default.
- W1897943175 hasRelatedWork W2169541461 @default.
- W1897943175 hasRelatedWork W2233439010 @default.
- W1897943175 hasRelatedWork W2465730666 @default.
- W1897943175 hasRelatedWork W2528361514 @default.
- W1897943175 hasRelatedWork W2560004025 @default.
- W1897943175 hasRelatedWork W2605353548 @default.
- W1897943175 hasRelatedWork W2769065924 @default.
- W1897943175 hasRelatedWork W2784315996 @default.
- W1897943175 hasRelatedWork W2792581785 @default.
- W1897943175 hasRelatedWork W2804294746 @default.
- W1897943175 hasRelatedWork W2907367312 @default.
- W1897943175 hasRelatedWork W2951389966 @default.
- W1897943175 hasRelatedWork W2999088353 @default.
- W1897943175 hasRelatedWork W3008859112 @default.
- W1897943175 hasRelatedWork W3014079452 @default.
- W1897943175 hasRelatedWork W3200225750 @default.
- W1897943175 hasRelatedWork W66957161 @default.
- W1897943175 isParatext "false" @default.
- W1897943175 isRetracted "false" @default.
- W1897943175 magId "1897943175" @default.
- W1897943175 workType "article" @default.