Matches in SemOpenAlex for { <https://semopenalex.org/work/W1897955994> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1897955994 endingPage "4" @default.
- W1897955994 startingPage "14" @default.
- W1897955994 abstract "Clozapine was discovered in 1959 but withheld from the United States market after several deaths due to agranulocytosis. The medication was approved in the United States in 1989 on a compassionate-use basis and was first marketed in 1990 as Clozaril. In 1999, following approval by the U.S. Food and Drug Administration, Zenith Goldline Pharmaceuticals (ZGP) introduced a generic form of clozapine.After 5 weeks of data collection (phase I), 24 patients were randomly assigned to group A and 21 patients to group B. Patients had DSM-IV diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, or atypical psychosis with mood disorder. In phase II, group A received a mean daily dose of 630 mg of generic clozapine, and group B continued to receive Clozaril at a mean daily dose of 610 mg, each for 8 weeks. In phase III, group A was reassigned to Clozaril, and group B was switched to generic clozapine, each for 8 weeks. At the end of phase III, group B resumed Clozaril. Efficacy was measured with the Clinical Global Impressions-Improvement (CGI-I) scale, the Brief Psychiatric Rating Scale (BPRS), and the Beck Depression Inventory (BDI).Five patients experienced relapse when they were switched from Clozaril to generic clozapine. Eleven patients worsened short of full relapse, 9 while receiving ZGP generic clozapine and 2 while receiving Clozaril. CGI-I scores and BPRS scores favored patients receiving Clozaril significantly. Only BDI scores favored patients receiving generic clozapine significantly.Until more studies have been performed, clinicians and administrators should carefully monitor stable Clozaril-treated patients who are being switched to generic clozapine." @default.
- W1897955994 created "2016-06-24" @default.
- W1897955994 creator A5027697923 @default.
- W1897955994 creator A5039546421 @default.
- W1897955994 creator A5086134684 @default.
- W1897955994 creator A5090904495 @default.
- W1897955994 date "2001-01-01" @default.
- W1897955994 modified "2023-10-17" @default.
- W1897955994 title "Clinical effects of a randomized switch of patients from clozaril to generic clozapine." @default.
- W1897955994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11305843" @default.
- W1897955994 hasPublicationYear "2001" @default.
- W1897955994 type Work @default.
- W1897955994 sameAs 1897955994 @default.
- W1897955994 citedByCount "26" @default.
- W1897955994 countsByYear W18979559942012 @default.
- W1897955994 countsByYear W18979559942013 @default.
- W1897955994 countsByYear W18979559942014 @default.
- W1897955994 countsByYear W18979559942015 @default.
- W1897955994 countsByYear W18979559942016 @default.
- W1897955994 countsByYear W18979559942020 @default.
- W1897955994 countsByYear W18979559942023 @default.
- W1897955994 crossrefType "journal-article" @default.
- W1897955994 hasAuthorship W1897955994A5027697923 @default.
- W1897955994 hasAuthorship W1897955994A5039546421 @default.
- W1897955994 hasAuthorship W1897955994A5086134684 @default.
- W1897955994 hasAuthorship W1897955994A5090904495 @default.
- W1897955994 hasConcept C118552586 @default.
- W1897955994 hasConcept C126322002 @default.
- W1897955994 hasConcept C138496976 @default.
- W1897955994 hasConcept C15744967 @default.
- W1897955994 hasConcept C2776174506 @default.
- W1897955994 hasConcept C2776412080 @default.
- W1897955994 hasConcept C2778528637 @default.
- W1897955994 hasConcept C2779727114 @default.
- W1897955994 hasConcept C2780325297 @default.
- W1897955994 hasConcept C2780733359 @default.
- W1897955994 hasConcept C2780864610 @default.
- W1897955994 hasConcept C71924100 @default.
- W1897955994 hasConcept C83849319 @default.
- W1897955994 hasConceptScore W1897955994C118552586 @default.
- W1897955994 hasConceptScore W1897955994C126322002 @default.
- W1897955994 hasConceptScore W1897955994C138496976 @default.
- W1897955994 hasConceptScore W1897955994C15744967 @default.
- W1897955994 hasConceptScore W1897955994C2776174506 @default.
- W1897955994 hasConceptScore W1897955994C2776412080 @default.
- W1897955994 hasConceptScore W1897955994C2778528637 @default.
- W1897955994 hasConceptScore W1897955994C2779727114 @default.
- W1897955994 hasConceptScore W1897955994C2780325297 @default.
- W1897955994 hasConceptScore W1897955994C2780733359 @default.
- W1897955994 hasConceptScore W1897955994C2780864610 @default.
- W1897955994 hasConceptScore W1897955994C71924100 @default.
- W1897955994 hasConceptScore W1897955994C83849319 @default.
- W1897955994 hasLocation W18979559941 @default.
- W1897955994 hasOpenAccess W1897955994 @default.
- W1897955994 hasPrimaryLocation W18979559941 @default.
- W1897955994 hasRelatedWork W14681528 @default.
- W1897955994 hasRelatedWork W1976820388 @default.
- W1897955994 hasRelatedWork W2010931051 @default.
- W1897955994 hasRelatedWork W2070784948 @default.
- W1897955994 hasRelatedWork W2077868834 @default.
- W1897955994 hasRelatedWork W2242300594 @default.
- W1897955994 hasRelatedWork W2413120190 @default.
- W1897955994 hasRelatedWork W2607046732 @default.
- W1897955994 hasRelatedWork W2726743474 @default.
- W1897955994 hasRelatedWork W59918674 @default.
- W1897955994 hasVolume "62 Suppl 5" @default.
- W1897955994 isParatext "false" @default.
- W1897955994 isRetracted "false" @default.
- W1897955994 magId "1897955994" @default.
- W1897955994 workType "article" @default.