Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898196193> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1898196193 endingPage "2600" @default.
- W1898196193 startingPage "2596" @default.
- W1898196193 abstract "IgA1 proteases from H. influenzae, N. meningitidis, S. pneumoniae, and S. sanguis were compared with respect to site of cleavage in the IgA1 molecule and EDTA sensitivity. Proteases from S. sanguis and S. pneumoniae cleaved the Pro (227)-Thr (228) bond within the hinge region of the alpha 1 chain and were inhibited by EDTA. H. influenzae IgA1 protease cleaved the Pro (231)-Ser (232) peptide bond. The activity of IgA1 proteases from H. influenzae and N. meningitidis was unaffected by EDTA. Purified and denatured alpha 1 chain was cleaved only in the hinge region. Other component chains of secretory IgA (secretory component, light and J chains) were not susceptible. In addition to IgA1 protease, S. pneumoniae released exo- and endoglycosidases that removed a considerable portion of carbohydrate side chains of IgA1; this activity was absent from crude IgA1 protease preparations of the other three bacterial species. Association in vitro of polymeric IgA1 with SC did not inhibit the degradation of IgA1 proteases. The considerable resistance of secretory IgA to cleavage by IgA1 proteases may be explained in part by the presence of IgA1 protease-neutralizing antibodies in secretory IgA." @default.
- W1898196193 created "2016-06-24" @default.
- W1898196193 creator A5013003363 @default.
- W1898196193 creator A5014142364 @default.
- W1898196193 creator A5018479302 @default.
- W1898196193 creator A5075642798 @default.
- W1898196193 creator A5086074728 @default.
- W1898196193 date "1980-06-01" @default.
- W1898196193 modified "2023-10-13" @default.
- W1898196193 title "IgA1 proteases from Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, and Streptococcus sanguis: comparative immunochemical studies." @default.
- W1898196193 doi "https://doi.org/10.4049/jimmunol.124.6.2596" @default.
- W1898196193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6768797" @default.
- W1898196193 hasPublicationYear "1980" @default.
- W1898196193 type Work @default.
- W1898196193 sameAs 1898196193 @default.
- W1898196193 citedByCount "87" @default.
- W1898196193 countsByYear W18981961932012 @default.
- W1898196193 countsByYear W18981961932013 @default.
- W1898196193 countsByYear W18981961932014 @default.
- W1898196193 countsByYear W18981961932015 @default.
- W1898196193 countsByYear W18981961932017 @default.
- W1898196193 countsByYear W18981961932021 @default.
- W1898196193 countsByYear W18981961932022 @default.
- W1898196193 crossrefType "journal-article" @default.
- W1898196193 hasAuthorship W1898196193A5013003363 @default.
- W1898196193 hasAuthorship W1898196193A5014142364 @default.
- W1898196193 hasAuthorship W1898196193A5018479302 @default.
- W1898196193 hasAuthorship W1898196193A5075642798 @default.
- W1898196193 hasAuthorship W1898196193A5086074728 @default.
- W1898196193 hasBestOaLocation W18981961931 @default.
- W1898196193 hasConcept C151730666 @default.
- W1898196193 hasConcept C159654299 @default.
- W1898196193 hasConcept C175156509 @default.
- W1898196193 hasConcept C181199279 @default.
- W1898196193 hasConcept C182220744 @default.
- W1898196193 hasConcept C185592680 @default.
- W1898196193 hasConcept C203014093 @default.
- W1898196193 hasConcept C2776714187 @default.
- W1898196193 hasConcept C2776925733 @default.
- W1898196193 hasConcept C2777068557 @default.
- W1898196193 hasConcept C2778458888 @default.
- W1898196193 hasConcept C2779102806 @default.
- W1898196193 hasConcept C2780898057 @default.
- W1898196193 hasConcept C2781253189 @default.
- W1898196193 hasConcept C43369102 @default.
- W1898196193 hasConcept C501593827 @default.
- W1898196193 hasConcept C523546767 @default.
- W1898196193 hasConcept C54355233 @default.
- W1898196193 hasConcept C55493867 @default.
- W1898196193 hasConcept C86803240 @default.
- W1898196193 hasConcept C89423630 @default.
- W1898196193 hasConceptScore W1898196193C151730666 @default.
- W1898196193 hasConceptScore W1898196193C159654299 @default.
- W1898196193 hasConceptScore W1898196193C175156509 @default.
- W1898196193 hasConceptScore W1898196193C181199279 @default.
- W1898196193 hasConceptScore W1898196193C182220744 @default.
- W1898196193 hasConceptScore W1898196193C185592680 @default.
- W1898196193 hasConceptScore W1898196193C203014093 @default.
- W1898196193 hasConceptScore W1898196193C2776714187 @default.
- W1898196193 hasConceptScore W1898196193C2776925733 @default.
- W1898196193 hasConceptScore W1898196193C2777068557 @default.
- W1898196193 hasConceptScore W1898196193C2778458888 @default.
- W1898196193 hasConceptScore W1898196193C2779102806 @default.
- W1898196193 hasConceptScore W1898196193C2780898057 @default.
- W1898196193 hasConceptScore W1898196193C2781253189 @default.
- W1898196193 hasConceptScore W1898196193C43369102 @default.
- W1898196193 hasConceptScore W1898196193C501593827 @default.
- W1898196193 hasConceptScore W1898196193C523546767 @default.
- W1898196193 hasConceptScore W1898196193C54355233 @default.
- W1898196193 hasConceptScore W1898196193C55493867 @default.
- W1898196193 hasConceptScore W1898196193C86803240 @default.
- W1898196193 hasConceptScore W1898196193C89423630 @default.
- W1898196193 hasIssue "6" @default.
- W1898196193 hasLocation W18981961931 @default.
- W1898196193 hasLocation W18981961932 @default.
- W1898196193 hasOpenAccess W1898196193 @default.
- W1898196193 hasPrimaryLocation W18981961931 @default.
- W1898196193 hasRelatedWork W13934227 @default.
- W1898196193 hasRelatedWork W1499852576 @default.
- W1898196193 hasRelatedWork W1674399591 @default.
- W1898196193 hasRelatedWork W1898196193 @default.
- W1898196193 hasRelatedWork W1968008266 @default.
- W1898196193 hasRelatedWork W2107411198 @default.
- W1898196193 hasRelatedWork W2145157298 @default.
- W1898196193 hasRelatedWork W2166498153 @default.
- W1898196193 hasRelatedWork W2943766196 @default.
- W1898196193 hasRelatedWork W1771548702 @default.
- W1898196193 hasVolume "124" @default.
- W1898196193 isParatext "false" @default.
- W1898196193 isRetracted "false" @default.
- W1898196193 magId "1898196193" @default.
- W1898196193 workType "article" @default.