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- W1898205944 abstract "Introduction: Although efficacious in stroke prevention in non-valvular atrial fibrillation (NVAF), many warfarin patients are sub-optimally managed. Out-of-range INR values have been associated with increased risk of thrombosis and bleeding. Little is known about INR control and clinical events in NVAF patients with comorbid diabetes. Objective: To evaluate the association of INR control and clinical outcomes among new warfarin patients with NVAF and diabetes in the US. Methods: Adult NVAF patients with diabetes who newly initiated warfarin were selected from the Veterans Health Administration Medical datasets for the duration 10/2007 through 9/2012. Valid INR values (0.5≤INR≤ 20) were examined from the warfarin initiation date through the earlier of first clinical outcome, end of warfarin use, or death. Each patient contributed multiple periods of in-range (2≤INR≤3) and out-of-range (INR 3) values. The relative risk ratios (RRR) of clinical outcomes associated with INR control were estimated. Results: Of 34,346 NVAF patients, 39.5% (13,577) had baseline diabetes. Table 1 shows the incidence associated with INR 3 respectively for the overall and the diabetic populations. Poisson regression showed that INR 3 was not significantly associated with increased risk of any of the clinical outcomes. Diabetes, despite an indicator of baseline cardiovascular risk, did not contribute to poor INR control. In fact, diabetes was associated with higher percent of time-in-therapeutic range, possibly reflecting more frequent health service encounters. Conclusions: In NVAF patients with diabetes, INR values of" @default.
- W1898205944 created "2016-06-24" @default.
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- W1898205944 date "2014-11-25" @default.
- W1898205944 modified "2023-09-22" @default.
- W1898205944 title "Abstract 12029: Association of Out-of-Range International Normalized Ratio (INR) Values and Adverse Clinical Outcomes Among Newly Initiated Warfarin Patients With Non-Valvular Atrial Fibrillation and Comorbid Diabetes" @default.
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