Matches in SemOpenAlex for { <https://semopenalex.org/work/W18982113> ?p ?o ?g. }
- W18982113 endingPage "158" @default.
- W18982113 startingPage "150" @default.
- W18982113 abstract "Oocyte maturation is a complex process involving nuclear and cytoplasmic maturation. The nuclear maturation is a chromosomal segregation and the cytoplasmic maturation involves the reorganization of the cytoplasmic organelles, mRNA transcription and storage of proteins to be used during fertilization and early embryo development. The mechanism of oocyte maturation in vivo and in vitro still are not totally understood. However it is generally accepted that the second messenger cyclic adenosine monophosphate (cAMP) plays a critical role in the maintenance of meiotic blockage of mammalian oocytes. A relative increase in the level of cAMP within the oocyte is essential for maintaining meiosis block, while a decrease in cAMP oocyte concentration allows the resumption of meiosis. The oocyte cAMP concentration is regulated by a balance of two types of enzymes: adenylate cyclase (AC) and phosphodiesterases (PDEs), which are responsible for the synthesis and degradation of cAMP, respectively. After being synthesized by AC in cumulus cells, cAMP are transferred to the oocyte through gap junctions. Thus, specific subtypes PDEs are able to inhibit or attenuate the spontaneous meiotic maturation of oocytes with PDE4 primarily involved in the metabolism of cAMP in granulosa cells and PDE3 in the oocyte. Although the immature oocytes can resume meiosis in vitro, after being removed from antral follicles, cytoplasmic maturation seems to occur asynchronously with nuclear maturation. Therefore, knowledge of the oocyte maturation process is fundamental for the development of methodologies to increase the success of in vitro embryo production and to develop treatments for various forms of infertility. This review will present current knowledge about the maintenance of the oocyte in prophase arrest, and the resumption of meiosis during oocyte maturation, focusing mainly on the changes that take place in the oocyte." @default.
- W18982113 created "2016-06-24" @default.
- W18982113 creator A5030074571 @default.
- W18982113 creator A5056025838 @default.
- W18982113 date "2014-07-01" @default.
- W18982113 modified "2023-10-02" @default.
- W18982113 title "Control of oocyte maturation" @default.
- W18982113 cites W1529991666 @default.
- W18982113 cites W1586278418 @default.
- W18982113 cites W17191093 @default.
- W18982113 cites W1899280238 @default.
- W18982113 cites W1965593095 @default.
- W18982113 cites W1967586250 @default.
- W18982113 cites W1968692185 @default.
- W18982113 cites W1969039586 @default.
- W18982113 cites W1970670075 @default.
- W18982113 cites W1979269306 @default.
- W18982113 cites W1985816197 @default.
- W18982113 cites W1990614593 @default.
- W18982113 cites W1995618372 @default.
- W18982113 cites W1999074203 @default.
- W18982113 cites W2003518121 @default.
- W18982113 cites W2009523739 @default.
- W18982113 cites W2013412768 @default.
- W18982113 cites W2014484676 @default.
- W18982113 cites W2020329015 @default.
- W18982113 cites W2025884210 @default.
- W18982113 cites W2025889581 @default.
- W18982113 cites W2031533876 @default.
- W18982113 cites W2032325024 @default.
- W18982113 cites W2032413267 @default.
- W18982113 cites W2035589292 @default.
- W18982113 cites W2041559739 @default.
- W18982113 cites W2048466881 @default.
- W18982113 cites W2050039745 @default.
- W18982113 cites W2051529474 @default.
- W18982113 cites W2054167608 @default.
- W18982113 cites W2054820071 @default.
- W18982113 cites W2062543923 @default.
- W18982113 cites W2065305930 @default.
- W18982113 cites W2068331270 @default.
- W18982113 cites W2069263862 @default.
- W18982113 cites W2072720547 @default.
- W18982113 cites W2074688515 @default.
- W18982113 cites W2075118421 @default.
- W18982113 cites W2077743651 @default.
- W18982113 cites W2078322680 @default.
- W18982113 cites W2086121206 @default.
- W18982113 cites W2091173216 @default.
- W18982113 cites W2095849729 @default.
- W18982113 cites W2097184870 @default.
- W18982113 cites W2099622050 @default.
- W18982113 cites W2101602571 @default.
- W18982113 cites W2109664810 @default.
- W18982113 cites W2111155686 @default.
- W18982113 cites W2117321372 @default.
- W18982113 cites W2118325095 @default.
- W18982113 cites W2120790606 @default.
- W18982113 cites W2126868334 @default.
- W18982113 cites W2128760314 @default.
- W18982113 cites W2140822361 @default.
- W18982113 cites W2143564478 @default.
- W18982113 cites W2152697478 @default.
- W18982113 cites W2158095419 @default.
- W18982113 cites W2169538778 @default.
- W18982113 cites W2258451270 @default.
- W18982113 cites W2350453513 @default.
- W18982113 cites W2503311955 @default.
- W18982113 cites W2907614158 @default.
- W18982113 cites W38995800 @default.
- W18982113 hasPublicationYear "2014" @default.
- W18982113 type Work @default.
- W18982113 sameAs 18982113 @default.
- W18982113 citedByCount "0" @default.
- W18982113 crossrefType "journal-article" @default.
- W18982113 hasAuthorship W18982113A5030074571 @default.
- W18982113 hasAuthorship W18982113A5056025838 @default.
- W18982113 hasConcept C104317684 @default.
- W18982113 hasConcept C148196450 @default.
- W18982113 hasConcept C179265757 @default.
- W18982113 hasConcept C181199279 @default.
- W18982113 hasConcept C196843134 @default.
- W18982113 hasConcept C2775966511 @default.
- W18982113 hasConcept C2776690073 @default.
- W18982113 hasConcept C54355233 @default.
- W18982113 hasConcept C55493867 @default.
- W18982113 hasConcept C62826618 @default.
- W18982113 hasConcept C86803240 @default.
- W18982113 hasConcept C95444343 @default.
- W18982113 hasConceptScore W18982113C104317684 @default.
- W18982113 hasConceptScore W18982113C148196450 @default.
- W18982113 hasConceptScore W18982113C179265757 @default.
- W18982113 hasConceptScore W18982113C181199279 @default.
- W18982113 hasConceptScore W18982113C196843134 @default.
- W18982113 hasConceptScore W18982113C2775966511 @default.
- W18982113 hasConceptScore W18982113C2776690073 @default.
- W18982113 hasConceptScore W18982113C54355233 @default.
- W18982113 hasConceptScore W18982113C55493867 @default.