Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898250196> ?p ?o ?g. }
- W1898250196 endingPage "2468" @default.
- W1898250196 startingPage "2461" @default.
- W1898250196 abstract "The downstream transcriptional factor of the hedgehog (Hh) pathway, GLI family zinc finger 1 (GLI1), plays a crucial role in regulating tumor progression. In the present study, we demonstrated that silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, exerts its anticancer capabilities by restraining GLI1 function in renal cell carcinoma (RCC) cells in vitro and in vivo. In the present study, we confirmed that silibinin induced growth inhibition of RCC through caspase-dependent apoptosis and downregulation of GLI1 and BCL2, which could be partially reversed by GLI1 overexpression. Moreover, we determined that the decreased GLI1 expression by silibinin was mediated by the mammalian target of rapamycin (mTOR) pathway. The in vivo mouse xenograft study also showed that silibinin significantly reduced RCC tumor growth and specifically targeted the mTOR-GLI1-BCL2 signaling pathway. In conclusion, our findings demonstrated for the first time that silibinin induces apoptosis of RCC cells through inhibition of the mTOR-GLI1‑BCL2 pathway. These findings also indicate that GLI1 is a novel regulator for the potential therapeutic application of silibinin against RCC." @default.
- W1898250196 created "2016-06-24" @default.
- W1898250196 creator A5001451095 @default.
- W1898250196 creator A5008074653 @default.
- W1898250196 creator A5025282415 @default.
- W1898250196 creator A5025595895 @default.
- W1898250196 creator A5044382433 @default.
- W1898250196 creator A5047005150 @default.
- W1898250196 creator A5063457618 @default.
- W1898250196 creator A5073593046 @default.
- W1898250196 creator A5075889094 @default.
- W1898250196 creator A5083512745 @default.
- W1898250196 creator A5085581217 @default.
- W1898250196 creator A5086783805 @default.
- W1898250196 creator A5086835192 @default.
- W1898250196 date "2015-08-26" @default.
- W1898250196 modified "2023-10-16" @default.
- W1898250196 title "Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma" @default.
- W1898250196 cites W1965431780 @default.
- W1898250196 cites W1965568759 @default.
- W1898250196 cites W1978878974 @default.
- W1898250196 cites W1984615933 @default.
- W1898250196 cites W1991899945 @default.
- W1898250196 cites W1994512948 @default.
- W1898250196 cites W2000572318 @default.
- W1898250196 cites W2002355858 @default.
- W1898250196 cites W2005942192 @default.
- W1898250196 cites W2025384240 @default.
- W1898250196 cites W2025663184 @default.
- W1898250196 cites W2035815822 @default.
- W1898250196 cites W2039205449 @default.
- W1898250196 cites W2039531276 @default.
- W1898250196 cites W2043834052 @default.
- W1898250196 cites W2045269572 @default.
- W1898250196 cites W2048254878 @default.
- W1898250196 cites W2049993265 @default.
- W1898250196 cites W2050943298 @default.
- W1898250196 cites W2052469687 @default.
- W1898250196 cites W2084750903 @default.
- W1898250196 cites W2085470568 @default.
- W1898250196 cites W2089179512 @default.
- W1898250196 cites W2090176557 @default.
- W1898250196 cites W2098136315 @default.
- W1898250196 cites W2099711571 @default.
- W1898250196 cites W2106912046 @default.
- W1898250196 cites W2108707301 @default.
- W1898250196 cites W2113950502 @default.
- W1898250196 cites W2114471035 @default.
- W1898250196 cites W2117137492 @default.
- W1898250196 cites W2122502982 @default.
- W1898250196 cites W2123914905 @default.
- W1898250196 cites W2138305199 @default.
- W1898250196 cites W2139499843 @default.
- W1898250196 cites W2146282577 @default.
- W1898250196 cites W2152432261 @default.
- W1898250196 cites W2169961966 @default.
- W1898250196 cites W2171469612 @default.
- W1898250196 cites W2768600953 @default.
- W1898250196 cites W340664217 @default.
- W1898250196 doi "https://doi.org/10.3892/or.2015.4224" @default.
- W1898250196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26323996" @default.
- W1898250196 hasPublicationYear "2015" @default.
- W1898250196 type Work @default.
- W1898250196 sameAs 1898250196 @default.
- W1898250196 citedByCount "23" @default.
- W1898250196 countsByYear W18982501962017 @default.
- W1898250196 countsByYear W18982501962018 @default.
- W1898250196 countsByYear W18982501962019 @default.
- W1898250196 countsByYear W18982501962020 @default.
- W1898250196 countsByYear W18982501962021 @default.
- W1898250196 countsByYear W18982501962022 @default.
- W1898250196 countsByYear W18982501962023 @default.
- W1898250196 crossrefType "journal-article" @default.
- W1898250196 hasAuthorship W1898250196A5001451095 @default.
- W1898250196 hasAuthorship W1898250196A5008074653 @default.
- W1898250196 hasAuthorship W1898250196A5025282415 @default.
- W1898250196 hasAuthorship W1898250196A5025595895 @default.
- W1898250196 hasAuthorship W1898250196A5044382433 @default.
- W1898250196 hasAuthorship W1898250196A5047005150 @default.
- W1898250196 hasAuthorship W1898250196A5063457618 @default.
- W1898250196 hasAuthorship W1898250196A5073593046 @default.
- W1898250196 hasAuthorship W1898250196A5075889094 @default.
- W1898250196 hasAuthorship W1898250196A5083512745 @default.
- W1898250196 hasAuthorship W1898250196A5085581217 @default.
- W1898250196 hasAuthorship W1898250196A5086783805 @default.
- W1898250196 hasAuthorship W1898250196A5086835192 @default.
- W1898250196 hasBestOaLocation W18982501961 @default.
- W1898250196 hasConcept C104317684 @default.
- W1898250196 hasConcept C127561419 @default.
- W1898250196 hasConcept C185592680 @default.
- W1898250196 hasConcept C190283241 @default.
- W1898250196 hasConcept C2777130413 @default.
- W1898250196 hasConcept C2779933373 @default.
- W1898250196 hasConcept C2781018059 @default.
- W1898250196 hasConcept C29537977 @default.
- W1898250196 hasConcept C502942594 @default.
- W1898250196 hasConcept C55493867 @default.
- W1898250196 hasConcept C62112901 @default.