Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898252364> ?p ?o ?g. }
- W1898252364 endingPage "3156" @default.
- W1898252364 startingPage "3149" @default.
- W1898252364 abstract "Vascular endothelial cell (EC) injury by lipopolysaccharides (LPS) plays a major role in the pathogenesis of gram-negative bacterial sepsis and endotoxic shock. The studies described here were performed to define further the molecular mechanisms involved in the EC responses to LPS. We showed that serum was required for LPS-mediated cytotoxicity for bovine brain microvessel, pulmonary, and aortic ECs and that anti-human CD14 antibodies completely blocked LPS-mediated cytotoxicity for ECs in the presence of human serum. The addition of a recombinant soluble form of human CD14 to serum-free medium restored the LPS-mediated cytotoxicity, whereas the addition of LPS binding protein (LBP), a serum protein that potentiates LPS-induced responses to monocytes, had no effect. A similar dependency on serum or recombinant soluble CD14 (under serum-free conditions) was observed for LPS-induced secretion of interleukin-6 by human umbilical vein ECs. These findings indicate that soluble CD14 is required for LPS-mediated EC responses independently of LPB, suggesting that serum soluble CD14 represents a naturally occurring agonist for EC responses to LPS." @default.
- W1898252364 created "2016-06-24" @default.
- W1898252364 creator A5012374811 @default.
- W1898252364 creator A5016165244 @default.
- W1898252364 creator A5040035646 @default.
- W1898252364 creator A5080139202 @default.
- W1898252364 creator A5080619204 @default.
- W1898252364 creator A5091299124 @default.
- W1898252364 date "1993-08-01" @default.
- W1898252364 modified "2023-10-16" @default.
- W1898252364 title "Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14" @default.
- W1898252364 cites W1458582449 @default.
- W1898252364 cites W1496624435 @default.
- W1898252364 cites W1501935155 @default.
- W1898252364 cites W1504299492 @default.
- W1898252364 cites W1510155660 @default.
- W1898252364 cites W1538608251 @default.
- W1898252364 cites W1539766563 @default.
- W1898252364 cites W1568761178 @default.
- W1898252364 cites W1582984670 @default.
- W1898252364 cites W1587675077 @default.
- W1898252364 cites W1659764698 @default.
- W1898252364 cites W1766658148 @default.
- W1898252364 cites W1891797115 @default.
- W1898252364 cites W1920456632 @default.
- W1898252364 cites W1967749363 @default.
- W1898252364 cites W1970131976 @default.
- W1898252364 cites W1983579326 @default.
- W1898252364 cites W1989961245 @default.
- W1898252364 cites W1997268553 @default.
- W1898252364 cites W200100059 @default.
- W1898252364 cites W2011291552 @default.
- W1898252364 cites W2022139778 @default.
- W1898252364 cites W2023788721 @default.
- W1898252364 cites W2029157767 @default.
- W1898252364 cites W2033855057 @default.
- W1898252364 cites W2038434279 @default.
- W1898252364 cites W2039088937 @default.
- W1898252364 cites W2042351236 @default.
- W1898252364 cites W2050496310 @default.
- W1898252364 cites W2054353677 @default.
- W1898252364 cites W2057905142 @default.
- W1898252364 cites W2062132955 @default.
- W1898252364 cites W2064626913 @default.
- W1898252364 cites W2068145342 @default.
- W1898252364 cites W2071196984 @default.
- W1898252364 cites W2085952814 @default.
- W1898252364 cites W2087934471 @default.
- W1898252364 cites W2093711314 @default.
- W1898252364 cites W2098335293 @default.
- W1898252364 cites W2098643663 @default.
- W1898252364 cites W2100994529 @default.
- W1898252364 cites W2101216734 @default.
- W1898252364 cites W2102790643 @default.
- W1898252364 cites W2107907376 @default.
- W1898252364 cites W2107948019 @default.
- W1898252364 cites W2122248986 @default.
- W1898252364 cites W2123987062 @default.
- W1898252364 cites W2141130289 @default.
- W1898252364 cites W2143282447 @default.
- W1898252364 cites W2148583002 @default.
- W1898252364 cites W2170495397 @default.
- W1898252364 cites W2180193525 @default.
- W1898252364 cites W2315951794 @default.
- W1898252364 cites W2322127597 @default.
- W1898252364 cites W2335178624 @default.
- W1898252364 cites W2417717664 @default.
- W1898252364 cites W2462960549 @default.
- W1898252364 cites W2467569826 @default.
- W1898252364 cites W275217836 @default.
- W1898252364 doi "https://doi.org/10.1128/iai.61.8.3149-3156.1993" @default.
- W1898252364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280982" @default.
- W1898252364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7687581" @default.
- W1898252364 hasPublicationYear "1993" @default.
- W1898252364 type Work @default.
- W1898252364 sameAs 1898252364 @default.
- W1898252364 citedByCount "160" @default.
- W1898252364 countsByYear W18982523642013 @default.
- W1898252364 countsByYear W18982523642014 @default.
- W1898252364 countsByYear W18982523642015 @default.
- W1898252364 countsByYear W18982523642016 @default.
- W1898252364 countsByYear W18982523642017 @default.
- W1898252364 countsByYear W18982523642018 @default.
- W1898252364 countsByYear W18982523642020 @default.
- W1898252364 countsByYear W18982523642022 @default.
- W1898252364 crossrefType "journal-article" @default.
- W1898252364 hasAuthorship W1898252364A5012374811 @default.
- W1898252364 hasAuthorship W1898252364A5016165244 @default.
- W1898252364 hasAuthorship W1898252364A5040035646 @default.
- W1898252364 hasAuthorship W1898252364A5080139202 @default.
- W1898252364 hasAuthorship W1898252364A5080619204 @default.
- W1898252364 hasAuthorship W1898252364A5091299124 @default.
- W1898252364 hasBestOaLocation W18982523641 @default.
- W1898252364 hasConcept C104317684 @default.
- W1898252364 hasConcept C109316439 @default.
- W1898252364 hasConcept C123012128 @default.
- W1898252364 hasConcept C202751555 @default.
- W1898252364 hasConcept C203014093 @default.