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- W1898304893 abstract "Abstract CXCL12 and its unique receptor CXCR4 , play important roles in inflammation and cancer metastasis. This study was undertaken to investigate the association of CXCL12 and CXCR4 polymorphisms with risk and prognosis of renal cell carcinoma ( RCC ) in the Chinese population. Blood was collected from 322 RCC patients and 402 healthy controls. The CXCL12 rs1801157G /A polymorphism and CXCR4 rs2228014C /T polymorphism were genotyped by polymerase chain reaction‐restriction fragment length polymorphism. Results showed that prevalence of CXCL12 rs1801157AA genotype was significantly increased in RCC cases than in controls [odds ratio ( OR ) = 3.07, 95% confidence interval ( CI ), 1.98–5.46, P = 6.1 × 10 −6 ; data were adjusted for age and sex]. Similarly, subjects carrying CXCR4 rs2228014CT or TT genotypes showed significantly high risk of RCC ( OR = 1.77, 95% CI , 1.28–2.71, P = 0.0003; OR = 4.01, 95% CI , 1.87–9.12, P = 7.8 × 10 −4 , respectively; data were adjusted for age and sex). When analyzing the survival time of RCC , patients with CXCL12 rs1801157AA genotype revealed significantly shorter survival time compared to cases with CXCL12 rs1801157GG and GA genotypes ( P = 0.001), whereas RCC patients carrying CXCR4 rs2228014CT and TT genotypes showed shorter survival time than the wild type ( P = 0.002). These data indicated that CXCL12 and CXCR4 may be new risk factors for RCC and could be used as prognostic markers for this malignancy." @default.
- W1898304893 created "2016-06-24" @default.
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- W1898304893 date "2013-08-19" @default.
- W1898304893 modified "2023-10-03" @default.
- W1898304893 title "Association of CXCL12 and CXCR4 gene polymorphisms with the susceptibility and prognosis of renal cell carcinoma" @default.
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- W1898304893 doi "https://doi.org/10.1111/tan.12170" @default.
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