FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898305340> ?p ?o ?g. }

• W1898305340 endingPage "6063" @default.
• W1898305340 startingPage "6053" @default.
• W1898305340 abstract "ABSTRACT AZD0914, a new spiropyrimidinetrione bacterial DNA gyrase inhibitor with a novel mode of inhibition, has activity against bacterial species commonly cultured from patient infection specimens, including fluoroquinolone-resistant isolates. This study assessed the in vitro activity of AZD0914 against key Gram-positive and fastidious Gram-negative clinical isolates collected globally in 2013. AZD0914 demonstrated potent activity, with MIC 90 s for AZD0914 of 0.25 mg/liter against Staphylococcus aureus ( n = 11,680), coagulase-negative staphylococci ( n = 1,923), streptococci ( n = 4,380), and Moraxella catarrhalis ( n = 145), 0.5 mg/liter against Staphylococcus lugdunensis ( n = 120) and Haemophilus influenzae ( n = 352), 1 mg/liter against Enterococcus faecalis ( n = 1,241), and 2 mg/liter against Haemophilus parainfluenzae ( n = 70). The activity against Enterococcus faecium was more limited (MIC 90 , 8 mg/liter). The spectrum and potency of AZD0914 included fluoroquinolone-resistant isolates in each species group, including methicillin-resistant staphylococci, penicillin-resistant streptococci, vancomycin-resistant enterococci, β-lactamase-producing Haemophilus spp., and M. catarrhalis . Based on these in vitro findings, AZD0914 warrants further investigation for its utility against a variety of Gram-positive and fastidious Gram-negative bacterial species." @default.
• W1898305340 created "2016-06-24" @default.
• W1898305340 creator A5012103893 @default.
• W1898305340 creator A5020290756 @default.
• W1898305340 creator A5038009031 @default.
• W1898305340 creator A5053492923 @default.
• W1898305340 creator A5063491070 @default.
• W1898305340 creator A5075544791 @default.
• W1898305340 date "2015-10-01" @default.
• W1898305340 modified "2023-10-11" @default.
• W1898305340 title "<i>In Vitro</i> Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens" @default.
• W1898305340 cites W1968451120 @default.
• W1898305340 cites W1976839752 @default.
• W1898305340 cites W1992733214 @default.
• W1898305340 cites W2010031792 @default.
• W1898305340 cites W2018011211 @default.
• W1898305340 cites W2019181491 @default.
• W1898305340 cites W2043609707 @default.
• W1898305340 cites W2044638013 @default.
• W1898305340 cites W2053770373 @default.
• W1898305340 cites W2053787856 @default.
• W1898305340 cites W2068572351 @default.
• W1898305340 cites W2086637524 @default.
• W1898305340 cites W2106048223 @default.
• W1898305340 cites W2117834417 @default.
• W1898305340 cites W2118681966 @default.
• W1898305340 cites W2122273366 @default.
• W1898305340 cites W2124162416 @default.
• W1898305340 cites W2131879020 @default.
• W1898305340 cites W2135826154 @default.
• W1898305340 cites W2135888335 @default.
• W1898305340 cites W2141672479 @default.
• W1898305340 cites W2165860378 @default.
• W1898305340 cites W2166756760 @default.
• W1898305340 cites W2176438233 @default.
• W1898305340 cites W82875543 @default.
• W1898305340 doi "https://doi.org/10.1128/aac.01016-15" @default.
• W1898305340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4576048" @default.
• W1898305340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26195518" @default.
• W1898305340 hasPublicationYear "2015" @default.
• W1898305340 type Work @default.
• W1898305340 sameAs 1898305340 @default.
• W1898305340 citedByCount "17" @default.
• W1898305340 countsByYear W18983053402016 @default.
• W1898305340 countsByYear W18983053402017 @default.
• W1898305340 countsByYear W18983053402019 @default.
• W1898305340 countsByYear W18983053402020 @default.
• W1898305340 countsByYear W18983053402022 @default.
• W1898305340 countsByYear W18983053402023 @default.
• W1898305340 crossrefType "journal-article" @default.
• W1898305340 hasAuthorship W1898305340A5012103893 @default.
• W1898305340 hasAuthorship W1898305340A5020290756 @default.
• W1898305340 hasAuthorship W1898305340A5038009031 @default.
• W1898305340 hasAuthorship W1898305340A5053492923 @default.
• W1898305340 hasAuthorship W1898305340A5063491070 @default.
• W1898305340 hasAuthorship W1898305340A5075544791 @default.
• W1898305340 hasBestOaLocation W18983053401 @default.
• W1898305340 hasConcept C104317684 @default.
• W1898305340 hasConcept C149453125 @default.
• W1898305340 hasConcept C167125095 @default.
• W1898305340 hasConcept C2776402342 @default.
• W1898305340 hasConcept C2776551000 @default.
• W1898305340 hasConcept C2776925733 @default.
• W1898305340 hasConcept C2777033495 @default.
• W1898305340 hasConcept C2777677444 @default.
• W1898305340 hasConcept C2779489039 @default.
• W1898305340 hasConcept C2779895986 @default.
• W1898305340 hasConcept C501593827 @default.
• W1898305340 hasConcept C523546767 @default.
• W1898305340 hasConcept C54355233 @default.
• W1898305340 hasConcept C547475151 @default.
• W1898305340 hasConcept C55493867 @default.
• W1898305340 hasConcept C86803240 @default.
• W1898305340 hasConcept C89423630 @default.
• W1898305340 hasConceptScore W1898305340C104317684 @default.
• W1898305340 hasConceptScore W1898305340C149453125 @default.
• W1898305340 hasConceptScore W1898305340C167125095 @default.
• W1898305340 hasConceptScore W1898305340C2776402342 @default.
• W1898305340 hasConceptScore W1898305340C2776551000 @default.
• W1898305340 hasConceptScore W1898305340C2776925733 @default.
• W1898305340 hasConceptScore W1898305340C2777033495 @default.
• W1898305340 hasConceptScore W1898305340C2777677444 @default.
• W1898305340 hasConceptScore W1898305340C2779489039 @default.
• W1898305340 hasConceptScore W1898305340C2779895986 @default.
• W1898305340 hasConceptScore W1898305340C501593827 @default.
• W1898305340 hasConceptScore W1898305340C523546767 @default.
• W1898305340 hasConceptScore W1898305340C54355233 @default.
• W1898305340 hasConceptScore W1898305340C547475151 @default.
• W1898305340 hasConceptScore W1898305340C55493867 @default.
• W1898305340 hasConceptScore W1898305340C86803240 @default.
• W1898305340 hasConceptScore W1898305340C89423630 @default.
• W1898305340 hasIssue "10" @default.
• W1898305340 hasLocation W18983053401 @default.
• W1898305340 hasLocation W18983053402 @default.
• W1898305340 hasLocation W18983053403 @default.
• W1898305340 hasOpenAccess W1898305340 @default.
• W1898305340 hasPrimaryLocation W18983053401 @default.
• W1898305340 hasRelatedWork W1791861904 @default.

• next