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• W1898306129 abstract "As gene polymorphisms of cytokines receptors have been found to significantly influence cell responses to cytokines, the aim of this study was to test the hypothesis that IFN-gamma receptor 1 (IFNGR1) gene polymorphisms may contribute to the pathogenesis of pre-eclampsia.One hundred and sixty-four pre-eclamptic patients (121 patients with mild pre-eclampsia and 43 patients with severe pre-eclampsia) and 171 controls were included. Polymorphisms of the IFNGR1 gene at positions -611, -270, +56 and +95 were genotyped with the matrix-assisted laser desorption/ionization time of flight mass spectrometry.This study showed a positive association between -56C/C genotype (OR = 1.7; 95% CI = 1.1-2.7) and pre-eclampsia. Although the genotype frequencies (except for -56C/C) of the two polymorphisms were comparable between cases and controls, higher frequency of the -611A/-56C haplotype (OR = 1.450; 95% CI = 1.070-1.966) was noticed in patients versus controls. All patients and controls were homozygous for the -270T/T and +95T/T genotypes. Specifically, the frequency of the -56C allele (OR = 1.838; 95% CI = 1.127-2.995) was higher among patients with severe pre-eclampsia.The IFNGR1 gene polymorphisms may contribute to the pathogenesis of pre-eclampsia in our population." @default.
• W1898306129 created "2016-06-24" @default.
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• W1898306129 date "2010-01-12" @default.
• W1898306129 modified "2023-09-28" @default.
• W1898306129 title "ORIGINAL ARTICLE: Contribution of Interferon-γ Receptor 1 Gene Polymorphisms to Pre-Eclampsia in China" @default.
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• W1898306129 doi "https://doi.org/10.1111/j.1600-0897.2009.00801.x" @default.
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