FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898376068> ?p ?o ?g. }

• W1898376068 endingPage "4437" @default.
• W1898376068 startingPage "4423" @default.
• W1898376068 abstract "Deciding whether or how to initiate a motor response to a stimulus can be surprisingly slow and the underlying processes are not well understood. The neuronal circuitry that allows frog tadpoles to swim in response to touch is well characterized and includes excitatory reticulospinal neurons that drive swim circuit neurons. Build-up of excitation to reticulospinal neurons is the key decision-making step for swimming. Asymmetry in this build-up between the two sides allows bilateral initiation at the same time as avoiding inappropriate co-activation of motor antagonists. Following stronger stimuli, reticulospinal neurons are excited through a trigeminal nucleus pathway and swimming starts first on the stimulated side. If this pathway fails or is lesioned, swimming starts later on the unstimulated side. The mechanisms underlying initiation of a simple tadpole motor response may share similarities with more complex decisions in other animals, including humans.Animals take time to make co-ordinated motor responses to a stimulus. How can sensory input initiate organized movements, activating all necessary elements at the same time as avoiding inappropriate co-excitation of antagonistic muscles? In vertebrates, this process usually results in the activation of reticulospinal pathways. Young Xenopus tadpoles can respond to head-skin touch by swimming, which may start on either side. We investigate how motor networks in the brain are organized, and whether asymmetries in touch sensory pathways avoid co-activation of antagonists at the same time as producing co-ordinated movements. We record from key reticulospinal neurons in the network controlling swimming. When the head skin is stimulated unilaterally, excitation builds up slowly and asymmetrically in these neurons such that those on both sides do not fire synchronously. This build-up of excitation to threshold is the key decision-making step and determines whether swimming will start, as well as on which side. In response to stronger stimuli, the stimulated side tends to 'win' because excitation from a shorter, trigeminal nucleus pathway becomes reliable and can initiate swimming earlier on the stimulated side. When this pathway fails or is lesioned, swimming starts later and on the unstimulated side. Stochasticity in the trigeminal nucleus pathway allows unpredictable turning behaviour to weaker stimuli, conferring potential survival benefits. We locate the longer, commissural sensory pathway carrying excitation to the unstimulated side and record from its neurons. These neurons fire to head-skin stimuli but excite reticulospinal neurons indirectly. We propose that asymmetries in the sensory pathways exciting brainstem reticulospinal neurons ensure alternating and co-ordinated swimming activity from the start." @default.
• W1898376068 created "2016-06-24" @default.
• W1898376068 creator A5006531380 @default.
• W1898376068 creator A5007608135 @default.
• W1898376068 creator A5035507950 @default.
• W1898376068 date "2015-07-30" @default.
• W1898376068 modified "2023-10-10" @default.
• W1898376068 title "Sensory initiation of a co-ordinated motor response: synaptic excitation underlying simple decision-making" @default.
• W1898376068 cites W1561619916 @default.
• W1898376068 cites W1564229154 @default.
• W1898376068 cites W1574030158 @default.
• W1898376068 cites W1965563123 @default.
• W1898376068 cites W1972785770 @default.
• W1898376068 cites W1980143518 @default.
• W1898376068 cites W1986436832 @default.
• W1898376068 cites W1989428010 @default.
• W1898376068 cites W1993875383 @default.
• W1898376068 cites W1998104411 @default.
• W1898376068 cites W2003641401 @default.
• W1898376068 cites W2009550261 @default.
• W1898376068 cites W2013720994 @default.
• W1898376068 cites W2013805868 @default.
• W1898376068 cites W2032229332 @default.
• W1898376068 cites W2038864504 @default.
• W1898376068 cites W2051186747 @default.
• W1898376068 cites W2051424476 @default.
• W1898376068 cites W2072146467 @default.
• W1898376068 cites W2072367043 @default.
• W1898376068 cites W2074911271 @default.
• W1898376068 cites W2076528110 @default.
• W1898376068 cites W2076773622 @default.
• W1898376068 cites W2078807031 @default.
• W1898376068 cites W2081970876 @default.
• W1898376068 cites W2083141675 @default.
• W1898376068 cites W2083364952 @default.
• W1898376068 cites W2087316358 @default.
• W1898376068 cites W2097506282 @default.
• W1898376068 cites W2106333818 @default.
• W1898376068 cites W2115050373 @default.
• W1898376068 cites W2127787712 @default.
• W1898376068 cites W2128080928 @default.
• W1898376068 cites W2132752513 @default.
• W1898376068 cites W2144797544 @default.
• W1898376068 cites W2165139782 @default.
• W1898376068 cites W2169134378 @default.
• W1898376068 cites W329593390 @default.
• W1898376068 cites W61787623 @default.
• W1898376068 doi "https://doi.org/10.1113/jp270792" @default.
• W1898376068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4594238" @default.
• W1898376068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26138033" @default.
• W1898376068 hasPublicationYear "2015" @default.
• W1898376068 type Work @default.
• W1898376068 sameAs 1898376068 @default.
• W1898376068 citedByCount "14" @default.
• W1898376068 countsByYear W18983760682015 @default.
• W1898376068 countsByYear W18983760682016 @default.
• W1898376068 countsByYear W18983760682017 @default.
• W1898376068 countsByYear W18983760682018 @default.
• W1898376068 countsByYear W18983760682019 @default.
• W1898376068 countsByYear W18983760682020 @default.
• W1898376068 countsByYear W18983760682021 @default.
• W1898376068 countsByYear W18983760682022 @default.
• W1898376068 crossrefType "journal-article" @default.
• W1898376068 hasAuthorship W1898376068A5006531380 @default.
• W1898376068 hasAuthorship W1898376068A5007608135 @default.
• W1898376068 hasAuthorship W1898376068A5035507950 @default.
• W1898376068 hasBestOaLocation W18983760681 @default.
• W1898376068 hasConcept C112592302 @default.
• W1898376068 hasConcept C15744967 @default.
• W1898376068 hasConcept C169760540 @default.
• W1898376068 hasConcept C17077164 @default.
• W1898376068 hasConcept C171139928 @default.
• W1898376068 hasConcept C180747234 @default.
• W1898376068 hasConcept C2779918689 @default.
• W1898376068 hasConcept C86803240 @default.
• W1898376068 hasConcept C94487597 @default.
• W1898376068 hasConceptScore W1898376068C112592302 @default.
• W1898376068 hasConceptScore W1898376068C15744967 @default.
• W1898376068 hasConceptScore W1898376068C169760540 @default.
• W1898376068 hasConceptScore W1898376068C17077164 @default.
• W1898376068 hasConceptScore W1898376068C171139928 @default.
• W1898376068 hasConceptScore W1898376068C180747234 @default.
• W1898376068 hasConceptScore W1898376068C2779918689 @default.
• W1898376068 hasConceptScore W1898376068C86803240 @default.
• W1898376068 hasConceptScore W1898376068C94487597 @default.
• W1898376068 hasFunder F4320334629 @default.
• W1898376068 hasIssue "19" @default.
• W1898376068 hasLocation W18983760681 @default.
• W1898376068 hasLocation W18983760682 @default.
• W1898376068 hasLocation W18983760683 @default.
• W1898376068 hasLocation W18983760684 @default.
• W1898376068 hasLocation W18983760685 @default.
• W1898376068 hasOpenAccess W1898376068 @default.
• W1898376068 hasPrimaryLocation W18983760681 @default.
• W1898376068 hasRelatedWork W1991880126 @default.
• W1898376068 hasRelatedWork W2039105804 @default.
• W1898376068 hasRelatedWork W2045706219 @default.
• W1898376068 hasRelatedWork W2079600992 @default.

• next