FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898389617> ?p ?o ?g. }

• W1898389617 endingPage "3000" @default.
• W1898389617 startingPage "2991" @default.
• W1898389617 abstract "Recent evidence that 5-hydroxytryptamine (5-HT or serotonin) enhances the release and the gene expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) suggests that 5-HT can excite the PVN magnocellular neurons. The objective of this study was to examine the underlying mechanisms for such excitatory action in the electrophysiologically identified hypothalamic PVN magnocellular neurons in rats using whole-cell patch-clamp. We found that 5-HT weakly depolarizes 33.3% of PVN magnocellular neurons in the presence of tetrodotoxin. A minuscule inward current was produced by 5-HT in 48% of the cells, which was attenuated when the 5-HT(4) antagonist GR113808 or the 5-HT(7) antagonist SB269970 was added. In addition, 5-HT reduced the frequency of miniature inhibitory postsynaptic currents in a dose-dependent manner. This inhibition was mimicked by the 5-HT(1B) agonist CP93129, and reversed in the presence of 5-HT(1B) antagonists cyanopindolol and SB224289. Besides, 5-HT induced a biphasic effect on the frequency of miniature excitatory postsynaptic currents, comprising a transient inhibition and a delayed concentration-dependent excitation (onset latency approximately 5 min). The facilitation was mimicked by the 5-HT(2A/2C) agonist DOI and abolished in the presence of the 5-HT(2C) antagonist RS102221. Our findings reveal that 5-HT directly increases the excitability of the PVN magnocellular neurons via multiple receptor subtypes and mechanisms. This may help understanding the regulation of 5-HT-induced hormone release and feeding behavior in the PVN." @default.
• W1898389617 created "2016-06-24" @default.
• W1898389617 creator A5007636085 @default.
• W1898389617 creator A5020730438 @default.
• W1898389617 creator A5072325848 @default.
• W1898389617 date "2007-05-01" @default.
• W1898389617 modified "2023-10-10" @default.
• W1898389617 title "Serotonin increases the excitability of the hypothalamic paraventricular nucleus magnocellular neurons" @default.
• W1898389617 cites W1484248909 @default.
• W1898389617 cites W1594847432 @default.
• W1898389617 cites W1600361555 @default.
• W1898389617 cites W1812219355 @default.
• W1898389617 cites W182682059 @default.
• W1898389617 cites W1848471352 @default.
• W1898389617 cites W1867285585 @default.
• W1898389617 cites W1891846574 @default.
• W1898389617 cites W194990313 @default.
• W1898389617 cites W1958860054 @default.
• W1898389617 cites W1964042817 @default.
• W1898389617 cites W1964165244 @default.
• W1898389617 cites W1972275518 @default.
• W1898389617 cites W1972816542 @default.
• W1898389617 cites W1976070297 @default.
• W1898389617 cites W1989715374 @default.
• W1898389617 cites W1994514599 @default.
• W1898389617 cites W1996097464 @default.
• W1898389617 cites W2002841699 @default.
• W1898389617 cites W2004313085 @default.
• W1898389617 cites W2005122802 @default.
• W1898389617 cites W2013384613 @default.
• W1898389617 cites W2015380890 @default.
• W1898389617 cites W2018862285 @default.
• W1898389617 cites W2023286290 @default.
• W1898389617 cites W2034951640 @default.
• W1898389617 cites W2038333053 @default.
• W1898389617 cites W2047371206 @default.
• W1898389617 cites W2047723877 @default.
• W1898389617 cites W2048868418 @default.
• W1898389617 cites W2050654001 @default.
• W1898389617 cites W2056075979 @default.
• W1898389617 cites W2057424192 @default.
• W1898389617 cites W2058269733 @default.
• W1898389617 cites W2067323832 @default.
• W1898389617 cites W2068411362 @default.
• W1898389617 cites W2069548567 @default.
• W1898389617 cites W2070290419 @default.
• W1898389617 cites W2074623978 @default.
• W1898389617 cites W2074667754 @default.
• W1898389617 cites W2079323180 @default.
• W1898389617 cites W2086006585 @default.
• W1898389617 cites W2086230387 @default.
• W1898389617 cites W2094531569 @default.
• W1898389617 cites W2101773578 @default.
• W1898389617 cites W2122261607 @default.
• W1898389617 cites W2128497690 @default.
• W1898389617 cites W2132011251 @default.
• W1898389617 cites W2143038141 @default.
• W1898389617 cites W2159001308 @default.
• W1898389617 cites W2159612818 @default.
• W1898389617 cites W2169699020 @default.
• W1898389617 cites W2181713049 @default.
• W1898389617 cites W2252415710 @default.
• W1898389617 cites W4250710147 @default.
• W1898389617 doi "https://doi.org/10.1111/j.1460-9568.2007.05547.x" @default.
• W1898389617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17561813" @default.
• W1898389617 hasPublicationYear "2007" @default.
• W1898389617 type Work @default.
• W1898389617 sameAs 1898389617 @default.
• W1898389617 citedByCount "37" @default.
• W1898389617 countsByYear W18983896172012 @default.
• W1898389617 countsByYear W18983896172014 @default.
• W1898389617 countsByYear W18983896172015 @default.
• W1898389617 countsByYear W18983896172016 @default.
• W1898389617 countsByYear W18983896172017 @default.
• W1898389617 countsByYear W18983896172018 @default.
• W1898389617 countsByYear W18983896172019 @default.
• W1898389617 countsByYear W18983896172020 @default.
• W1898389617 countsByYear W18983896172021 @default.
• W1898389617 countsByYear W18983896172022 @default.
• W1898389617 countsByYear W18983896172023 @default.
• W1898389617 crossrefType "journal-article" @default.
• W1898389617 hasAuthorship W1898389617A5007636085 @default.
• W1898389617 hasAuthorship W1898389617A5020730438 @default.
• W1898389617 hasAuthorship W1898389617A5072325848 @default.
• W1898389617 hasConcept C112592302 @default.
• W1898389617 hasConcept C126322002 @default.
• W1898389617 hasConcept C134018914 @default.
• W1898389617 hasConcept C169760540 @default.
• W1898389617 hasConcept C170493617 @default.
• W1898389617 hasConcept C17077164 @default.
• W1898389617 hasConcept C185592680 @default.
• W1898389617 hasConcept C197341189 @default.
• W1898389617 hasConcept C21158919 @default.
• W1898389617 hasConcept C2775864247 @default.
• W1898389617 hasConcept C2776176026 @default.
• W1898389617 hasConcept C2776741303 @default.
• W1898389617 hasConcept C2776885963 @default.
• W1898389617 hasConcept C2777687476 @default.

• next