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- W189854619 abstract "Nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of kinins and prostaglandins and stabilize leukocyte lysosomal membranes. Nonsteroidal anti-inflammatory drugs also weakly block the biosynthesis of histamine and serotonin, and pharmacologically antagonize kinins, prostaglandins and slow-reacting substance of anaphylaxis. Nonsteroidal anti-inflammatory drugs effectively control both cardiovascular and respiratory manifestations of hypersensitivity in cattle and horses. This, coupled with the contrasting lack of effectiveness of antiamine drugs, suggests that bio-amines such as histamine and serotonin (5-hydroxytryptamine) may be less important than kinins, postaglandins and slow-reacting substance in the mediation of the hypersensitivity/inflammatory reaction, at least in cardiopulmonary systems of these species. Nonsteroidal anti-inflammatory drugs justify more prominence in the clinical control of acute respiratory disease in domestic herbivores." @default.
- W189854619 created "2016-06-24" @default.
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- W189854619 date "1977-07-01" @default.
- W189854619 modified "2023-09-23" @default.
- W189854619 title "Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses." @default.
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- W189854619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1277585" @default.
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