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• W1898556857 abstract "BACKGROUND Prostatitis is one of the most common urological problems afflicting adult men. The etiology and pathogenesis of nonbacterial prostatitis, which accounts for 90–95% of cases, is largely unknown. As serum proteins often indicate the overall pathologic status of patients, we hypothesized that protein biomarkers of prostatitis might be identified by comparing the serum proteomes of patients with and without nonbacterial prostatitis. METHODS All untreated samples were collected from subjects attending the Fangchenggang Area Male Health and Examination Survey (FAMHES). We profiled pooled serum samples from four carefully selected groups of patients (n = 10/group) representing the various categories of nonbacterial prostatitis (IIIa, IIIb, and IV) and matched healthy controls using a mass spectrometry-based 4-plex iTRAQ proteomic approach. More than 160 samples were validated by ELISA. RESULTS Overall, 69 proteins were identified. Among them, 42, 52, and 37 proteins were identified with differential expression in Category IIIa, IIIb, and IV prostatitis, respectively. The 19 common proteins were related to immunity and defense, ion binding, transport, and proteolysis. Two zinc-binding proteins, superoxide dismutase 3 (SOD3), and carbonic anhydrase I (CA1), were significantly higher in all types of prostatitis than in the control. A receiver operating characteristic curve estimated sensitivities of 50.4 and 68.1% and specificities of 92.1 and 83.8% for CA1 and SOD3, respectively, in detecting nonbacterial prostatitis. The serum CA1 concentration was inversely correlated to the zinc concentration in expressed-prostatic secretions. CONCLUSIONS Our findings suggest that SOD3 and CA1 are potential diagnostic markers of nonbacterial prostatitis, although further large-scale studies are required. The molecular profiles of nonbacterial prostatitis pathogenesis may lay a foundation for discovery of new therapies. Prostate 75:1538–1555, 2015. © 2015 Wiley Periodicals, Inc." @default.
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• W1898556857 date "2015-05-22" @default.
• W1898556857 modified "2023-10-16" @default.
• W1898556857 title "Serum quantitative proteomic analysis reveals potential zinc-associated biomarkers for nonbacterial prostatitis" @default.
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• W1898556857 cites W1973214716 @default.
• W1898556857 cites W1976113916 @default.
• W1898556857 cites W1978999760 @default.
• W1898556857 cites W1979570571 @default.
• W1898556857 cites W1988028637 @default.
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• W1898556857 cites W1992468214 @default.
• W1898556857 cites W1996587226 @default.
• W1898556857 cites W2001175124 @default.
• W1898556857 cites W2002743779 @default.
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• W1898556857 cites W2014224471 @default.
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• W1898556857 cites W2027605011 @default.
• W1898556857 cites W2033657576 @default.
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• W1898556857 doi "https://doi.org/10.1002/pros.23028" @default.
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