Matches in SemOpenAlex for { <https://semopenalex.org/work/W1898672816> ?p ?o ?g. }
- W1898672816 endingPage "25" @default.
- W1898672816 startingPage "25" @default.
- W1898672816 abstract "Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family, including a low intrinsic GTPase activity.The functions of other Rab proteins have been defined through the use of dominant-negative mutants with amino acid substitutions in the conserved N(T)KxD nucleotide binding motif. Surprisingly, when such Rab24 constructs were expressed in cultured cells, they accumulated in nuclear inclusions which disrupted the integrity of the nuclear envelope. The inclusions reacted positively with antibodies against ubiquitin and Hsp70, similar to protein aggregates observed in polyglutamine disorders. They also appeared to sequester importin-beta and GFP-coupled glucocorticoid receptor. Other Rab GTPases with similar mutations in the N(T)KxD motif were never found in inclusions, suggesting that the unusual localization of Rab24 is not related solely to misfolding of its nucleotide-free form. Studies with Rab24/Rab1B chimeras indicated that targeting of the mutant protein to inclusions requires the unique C-terminal domain of Rab24.These studies demonstrate that mutations in Rab24 can trigger a cytopathic cellular response involving accumulation of nuclear inclusions. If the N(T)KxD mutants of Rab24 function as dominant suppressors, these studies may point to a unique role for Rab24 in degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope. However, we cannot yet eliminate the possibility that these phenomena are related to unusual non-physiological protein interactions with the mutant form of Rab24." @default.
- W1898672816 created "2016-06-24" @default.
- W1898672816 creator A5024897589 @default.
- W1898672816 creator A5037271165 @default.
- W1898672816 creator A5071310713 @default.
- W1898672816 creator A5076490478 @default.
- W1898672816 creator A5080039147 @default.
- W1898672816 date "2002-01-01" @default.
- W1898672816 modified "2023-10-12" @default.
- W1898672816 cites W1482432683 @default.
- W1898672816 cites W1486436311 @default.
- W1898672816 cites W1489286522 @default.
- W1898672816 cites W1513729579 @default.
- W1898672816 cites W1542442836 @default.
- W1898672816 cites W1565873176 @default.
- W1898672816 cites W1579960871 @default.
- W1898672816 cites W1595436183 @default.
- W1898672816 cites W1618691523 @default.
- W1898672816 cites W1622884348 @default.
- W1898672816 cites W1623300751 @default.
- W1898672816 cites W1752162927 @default.
- W1898672816 cites W1881270362 @default.
- W1898672816 cites W1940885739 @default.
- W1898672816 cites W1965260691 @default.
- W1898672816 cites W1968643089 @default.
- W1898672816 cites W1970654084 @default.
- W1898672816 cites W1973864992 @default.
- W1898672816 cites W1974829094 @default.
- W1898672816 cites W1975787569 @default.
- W1898672816 cites W1985474993 @default.
- W1898672816 cites W1987945169 @default.
- W1898672816 cites W1987945386 @default.
- W1898672816 cites W1988420272 @default.
- W1898672816 cites W1992553937 @default.
- W1898672816 cites W1993676838 @default.
- W1898672816 cites W1996281893 @default.
- W1898672816 cites W1997021573 @default.
- W1898672816 cites W1997525673 @default.
- W1898672816 cites W2007797957 @default.
- W1898672816 cites W2010142538 @default.
- W1898672816 cites W2013029120 @default.
- W1898672816 cites W2015091466 @default.
- W1898672816 cites W2019165280 @default.
- W1898672816 cites W2023766537 @default.
- W1898672816 cites W2024759430 @default.
- W1898672816 cites W2029091584 @default.
- W1898672816 cites W2032184683 @default.
- W1898672816 cites W2034120336 @default.
- W1898672816 cites W2034766627 @default.
- W1898672816 cites W2038966235 @default.
- W1898672816 cites W2040792888 @default.
- W1898672816 cites W2042871630 @default.
- W1898672816 cites W2043676179 @default.
- W1898672816 cites W2047137800 @default.
- W1898672816 cites W2052059014 @default.
- W1898672816 cites W2055041189 @default.
- W1898672816 cites W2056003065 @default.
- W1898672816 cites W2065378127 @default.
- W1898672816 cites W2068625958 @default.
- W1898672816 cites W2074574014 @default.
- W1898672816 cites W2077971829 @default.
- W1898672816 cites W2081174927 @default.
- W1898672816 cites W2081595285 @default.
- W1898672816 cites W2085432989 @default.
- W1898672816 cites W2087920955 @default.
- W1898672816 cites W2089741493 @default.
- W1898672816 cites W2107518823 @default.
- W1898672816 cites W2108943672 @default.
- W1898672816 cites W2115373693 @default.
- W1898672816 cites W2118434776 @default.
- W1898672816 cites W2119999468 @default.
- W1898672816 cites W2120689665 @default.
- W1898672816 cites W2121776150 @default.
- W1898672816 cites W2132513906 @default.
- W1898672816 cites W2136709809 @default.
- W1898672816 cites W2137938929 @default.
- W1898672816 cites W2138834926 @default.
- W1898672816 cites W2141143622 @default.
- W1898672816 cites W2144281053 @default.
- W1898672816 cites W2145065899 @default.
- W1898672816 cites W2149749269 @default.
- W1898672816 cites W2154883764 @default.
- W1898672816 cites W2157513658 @default.
- W1898672816 cites W2170437356 @default.
- W1898672816 cites W2410489225 @default.
- W1898672816 cites W4211016738 @default.
- W1898672816 cites W4211020343 @default.
- W1898672816 cites W4252368281 @default.
- W1898672816 doi "https://doi.org/10.1186/1471-2121-3-25" @default.
- W1898672816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/130051" @default.
- W1898672816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12323076" @default.
- W1898672816 hasPublicationYear "2002" @default.
- W1898672816 type Work @default.
- W1898672816 sameAs 1898672816 @default.
- W1898672816 citedByCount "15" @default.
- W1898672816 countsByYear W18986728162013 @default.
- W1898672816 countsByYear W18986728162014 @default.
- W1898672816 countsByYear W18986728162015 @default.