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• W1898771364 abstract "Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages. Vitamin D treatment of infected macrophages abrogated infection-induced accumulation of lipid droplets, which are required for intracellular M. tuberculosis growth. Additional transcriptomics results showed that vitamin D downregulates the proadipogenic peroxisome proliferator-activated receptor γ (PPARγ) in infected macrophages. PPARγ agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARγ signaling in regulating both vitamin D functions. These findings suggest the potential for host-based, adjunct antituberculosis therapy targeting lipid metabolism." @default.
• W1898771364 created "2016-06-24" @default.
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• W1898771364 date "2014-06-04" @default.
• W1898771364 modified "2023-10-14" @default.
• W1898771364 title "Cutting Edge: Vitamin D Regulates Lipid Metabolism in <i>Mycobacterium tuberculosis</i> Infection" @default.
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• W1898771364 doi "https://doi.org/10.4049/jimmunol.1400736" @default.
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