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- W189885090 abstract "ABSTRACT Knowledge of the signal transduction pathways involved in mediating the effects of oHA on target cells would be useful in defning potential selective targets for inhibitors of endothelial cell (EC) function in relevance to intervention in angiogenesis. We have previously shown that oHA induced mitogenesis involves activation of protein kinase C, MAP kinase and early response genes in bovine aortic EC (BAEC). Here we demonstrate the potential involvement of both G-protein and tyrosine kinase linked elements, suggesting the existence of cross-talk between separate signal transduction pathways. In the presence of oHA, both PLC γ1 and PLC β1, β2 and β3 were translocated to the plasma membrane. We also found that Gβ sub-units became strongly associated with PLC γ1, and and immuno-neutralising antibodies loaded into cells using liposome mediated delivery, significantly reduced MAP kinase tyrosine phosphorylation. Furthermore, MAP kinase tyrosine phosphorylation as well as cell proliferation were significantly reduced in the presence of pertussis toxin. Ras was also activated in oHA treated cells, and the potent ras inhibitor Ftase 1 significantly inhibited cell proliferation." @default.
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- W189885090 date "2002-01-01" @default.
- W189885090 modified "2023-09-23" @default.
- W189885090 title "SIGNAL TRANSDUCTION PATHWAYS IN HYALURONAN INDUCED PROLIFERATION OF ENDOTHELIAL CELLS" @default.
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- W189885090 doi "https://doi.org/10.1533/9781845693121.469" @default.
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