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• W1898859148 endingPage "5766" @default.
• W1898859148 startingPage "5756" @default.
• W1898859148 abstract "The mb-1 gene, encoding a membrane immunoglobulin-associated protein, is developmentally regulated and expressed specifically in pre-B and mature B lymphocytes. Analysis of the TATA-less mb-1 promoter indicated that it directs initiation of transcription from multiple sites. Promoter sequences between -68 and +70 conferred the correct pattern of cell type-specific transcription upon a heterologous gene. Two nuclear factor-binding sites that are important for promoter function were identified between -59 and -38. Both sites interacted with ubiquitous nuclear factors in vitro. One of these factors was identified as Sp1. Multimerized copies of both factor-binding sites augmented expression from a heterologous minimal promoter in both lymphoid and nonlymphoid cells, suggesting that additional mb-1 promoter sequences are involved in determining the correct cell type specificity. Analysis of the heterogeneity of transcription initiation indicated that a mutation which increased the distance between upstream sequences and the region of initiation resulted in the utilization of a novel set of initiation sites. Moreover, an insertion of a TATA element into the mb-1 promoter at -30 biased initiation of transcription to +1 but did not abolish the use of the other sites. Mutation of an initiator sequence homology encompassing one of the major initiation sites had only a minor effect on its utilization. From these data, we conclude that upstream factor-binding sites in the TATA-less mb-1 promoter define a region in which initiation of transcription occurs at multiple sites." @default.
• W1898859148 created "2016-06-24" @default.
• W1898859148 creator A5022682784 @default.
• W1898859148 creator A5046087419 @default.
• W1898859148 creator A5058239452 @default.
• W1898859148 date "1991-11-01" @default.
• W1898859148 modified "2023-10-16" @default.
• W1898859148 title "Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences." @default.
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• W1898859148 doi "https://doi.org/10.1128/mcb.11.11.5756" @default.
• W1898859148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/361947" @default.
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• W1898859148 hasPublicationYear "1991" @default.
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