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- W1898882145 abstract "Abstract OBJECTIVES: Primary sjögren syndrome is a systemic autoimmune disease characterized by immune system abnormalities. It’s unclear how melatonin influences the immune responses. In this study we investigated the levels of serum melatonin in sjögren patients and melatonin’s diurnal rhythm. METHOD: In this study, 47 sjögren patients (35 female, 12 male, mean age 39,7 ± 11,5 years, mean disease duration 8,2 ± 2,7 years) and 28 healthy controls ( 21 female, 7 male, mean age 41,3± 7,7 years) were included. Serum melatonin levels were measured by ELISA, in the morning and night. RESULTS: In the sjögren patients group; the mean serum melatonin levels were 49, 2 ± 12,3 at night and 52,6 ± 5,1 in the morning. In the healthy control group; the mean serum melatonin levels were 77,1 ± 12,9 at night and 27,2 ± 6,1 in the morning. There was significant change in the diurnal rhythm of the melatonin in the sjögren patient group. Melatonin secretion at night was found to be lower, in the SSc patient group than the healthy control group, but in the morning was found to be higher. Those were statically significant (p<0.001, p<0.001 respectively). In the patient group, there was no statically significant difference between the serum levels in the morning and night. CONCLUSION: In this study, we found that diurnal rhythm of the melatonin changed in sjögren patients. These findings can be due to the effects of melatonin on the inflammatory responses." @default.
- W1898882145 created "2016-06-24" @default.
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- W1898882145 date "2014-05-01" @default.
- W1898882145 modified "2023-10-15" @default.
- W1898882145 title "Serum Melatonin levels in Sjögren patients (HUM7P.310)" @default.
- W1898882145 doi "https://doi.org/10.4049/jimmunol.192.supp.184.19" @default.
- W1898882145 hasPublicationYear "2014" @default.
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