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- W1898990505 endingPage "e0138236" @default.
- W1898990505 startingPage "e0138236" @default.
- W1898990505 abstract "Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly understood. In this study, we analysed lncRNA expression during human B-cell development by array-based expression profiling of eleven distinct flow-sorted B-cell subsets, comprising pre-B1, pre-B2, immature, naive, memory, and plasma cells from bone marrow biopsies (n = 7), and naive, centroblast, centrocyte, memory, and plasmablast cells from tonsil tissue samples (n = 6), respectively. A remapping strategy was used to assign the array probes to 37630 gene-level probe sets, reflecting recent updates in genomic and transcriptomic databases, which enabled expression profiling of 19579 long noncoding RNAs, comprising 3947 antisense RNAs, 5277 lincRNAs, 7625 pseudogenes, and 2730 additional lncRNAs. As a first step towards inferring the functions of the identified lncRNAs in developing B-cells, we analysed their co-expression with well-characterized protein-coding genes, a method known as guilt by association. By using weighted gene co-expression network analysis, we identified 272 lincRNAs, 471 antisense RNAs, 376 pseudogene RNAs, and 64 lncRNAs within seven sub-networks associated with distinct stages of B-cell development, such as early B-cell development, B-cell proliferation, affinity maturation of antibody, and terminal differentiation. These data provide an important resource for future studies on the functions of lncRNAs in development of the adaptive immune response, and the pathogenesis of B-cell malignancies that originate from distinct B-cell subpopulations." @default.
- W1898990505 created "2016-06-24" @default.
- W1898990505 creator A5010675319 @default.
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- W1898990505 date "2015-09-22" @default.
- W1898990505 modified "2023-10-15" @default.
- W1898990505 title "Long Noncoding RNA Expression during Human B-Cell Development" @default.
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- W1898990505 doi "https://doi.org/10.1371/journal.pone.0138236" @default.
- W1898990505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4578992" @default.
- W1898990505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26394393" @default.