Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899016823> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1899016823 endingPage "29" @default.
- W1899016823 startingPage "619" @default.
- W1899016823 abstract "(-)-Norepinephrine is the principal neurotransmitter of the mammalian sympathetic nervous system and a major CNS neurotransmitter. The simple ring fluorinated derivatives of (-)- and (+)-norepinephrine [(-)- and (+)6-fluoronorepinephrine] and dopamine (6-fluorodopamine) have been labeled with 18F in high specific activity (2-5 Ci/mumol) and evaluated as tracers for (-)-norepinephrine. Comparative PET studies of (-) and (+)-6-[18F]fluoronorepinephrine [(-)-6-[18F]FNE and (+)-6-[18F]FNE] and 6-[18F]fluorodopamine (6-[18F]FDA) in the same baboon showed strikingly different kinetics in the heart. Analysis of plasma showed more rapid metabolism of 6-[18F]FDA with only 1%-2% of 18F remaining as parent tracer at 10 min after injection of 6-[18F]FDA, in contrast to 28% and 17% remaining after injection of (-) and (+)-6-[18F]FNE. No changes in vital signs were observed at any time during the study. Pretreatment with desipramine (0.5 mg/kg), a tricyclic antidepressant drug which interacts with a binding site associated with norepinephrine reuptake, markedly decreased cardiac uptake of 6-[18F]FDA and (-)-6-[18F]FNE. However, a greater blocking effect was observed for (-)-6-[18F]FNE. These studies show that (-) and (+)-6-[18F]FNE are similar to (-)- and (+)-norepinephrine in their patterns of metabolism and clearance in the heart and that (-)-6-[18F]FNE is a promising tracer for endogenous (-)-norepinephrine." @default.
- W1899016823 created "2016-06-24" @default.
- W1899016823 creator A5002969658 @default.
- W1899016823 creator A5004808486 @default.
- W1899016823 creator A5016255318 @default.
- W1899016823 creator A5019780098 @default.
- W1899016823 creator A5040402480 @default.
- W1899016823 creator A5046703997 @default.
- W1899016823 creator A5055941537 @default.
- W1899016823 creator A5074124459 @default.
- W1899016823 creator A5087752085 @default.
- W1899016823 date "1993-04-01" @default.
- W1899016823 modified "2023-10-18" @default.
- W1899016823 title "Comparison of high specific activity (-) and (+)-6-[18F]fluoronorepinephrine and 6-[18F]fluorodopamine in baboons: heart uptake, metabolism and the effect of desipramine." @default.
- W1899016823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8455079" @default.
- W1899016823 hasPublicationYear "1993" @default.
- W1899016823 type Work @default.
- W1899016823 sameAs 1899016823 @default.
- W1899016823 citedByCount "16" @default.
- W1899016823 countsByYear W18990168232015 @default.
- W1899016823 countsByYear W18990168232018 @default.
- W1899016823 crossrefType "journal-article" @default.
- W1899016823 hasAuthorship W1899016823A5002969658 @default.
- W1899016823 hasAuthorship W1899016823A5004808486 @default.
- W1899016823 hasAuthorship W1899016823A5016255318 @default.
- W1899016823 hasAuthorship W1899016823A5019780098 @default.
- W1899016823 hasAuthorship W1899016823A5040402480 @default.
- W1899016823 hasAuthorship W1899016823A5046703997 @default.
- W1899016823 hasAuthorship W1899016823A5055941537 @default.
- W1899016823 hasAuthorship W1899016823A5074124459 @default.
- W1899016823 hasAuthorship W1899016823A5087752085 @default.
- W1899016823 hasConcept C126322002 @default.
- W1899016823 hasConcept C134018914 @default.
- W1899016823 hasConcept C170493617 @default.
- W1899016823 hasConcept C176233148 @default.
- W1899016823 hasConcept C178790620 @default.
- W1899016823 hasConcept C185592680 @default.
- W1899016823 hasConcept C2775841634 @default.
- W1899016823 hasConcept C2775864247 @default.
- W1899016823 hasConcept C2776219046 @default.
- W1899016823 hasConcept C2778514916 @default.
- W1899016823 hasConcept C2779177272 @default.
- W1899016823 hasConcept C2779594886 @default.
- W1899016823 hasConcept C2780250439 @default.
- W1899016823 hasConcept C2781081902 @default.
- W1899016823 hasConcept C2781161787 @default.
- W1899016823 hasConcept C513476851 @default.
- W1899016823 hasConcept C529278444 @default.
- W1899016823 hasConcept C62231903 @default.
- W1899016823 hasConcept C71924100 @default.
- W1899016823 hasConcept C98274493 @default.
- W1899016823 hasConcept C99631742 @default.
- W1899016823 hasConceptScore W1899016823C126322002 @default.
- W1899016823 hasConceptScore W1899016823C134018914 @default.
- W1899016823 hasConceptScore W1899016823C170493617 @default.
- W1899016823 hasConceptScore W1899016823C176233148 @default.
- W1899016823 hasConceptScore W1899016823C178790620 @default.
- W1899016823 hasConceptScore W1899016823C185592680 @default.
- W1899016823 hasConceptScore W1899016823C2775841634 @default.
- W1899016823 hasConceptScore W1899016823C2775864247 @default.
- W1899016823 hasConceptScore W1899016823C2776219046 @default.
- W1899016823 hasConceptScore W1899016823C2778514916 @default.
- W1899016823 hasConceptScore W1899016823C2779177272 @default.
- W1899016823 hasConceptScore W1899016823C2779594886 @default.
- W1899016823 hasConceptScore W1899016823C2780250439 @default.
- W1899016823 hasConceptScore W1899016823C2781081902 @default.
- W1899016823 hasConceptScore W1899016823C2781161787 @default.
- W1899016823 hasConceptScore W1899016823C513476851 @default.
- W1899016823 hasConceptScore W1899016823C529278444 @default.
- W1899016823 hasConceptScore W1899016823C62231903 @default.
- W1899016823 hasConceptScore W1899016823C71924100 @default.
- W1899016823 hasConceptScore W1899016823C98274493 @default.
- W1899016823 hasConceptScore W1899016823C99631742 @default.
- W1899016823 hasIssue "4" @default.
- W1899016823 hasLocation W18990168231 @default.
- W1899016823 hasOpenAccess W1899016823 @default.
- W1899016823 hasPrimaryLocation W18990168231 @default.
- W1899016823 hasRelatedWork W1899016823 @default.
- W1899016823 hasRelatedWork W1938687485 @default.
- W1899016823 hasRelatedWork W1963890972 @default.
- W1899016823 hasRelatedWork W1983415715 @default.
- W1899016823 hasRelatedWork W1990763434 @default.
- W1899016823 hasRelatedWork W1994930347 @default.
- W1899016823 hasRelatedWork W2000405680 @default.
- W1899016823 hasRelatedWork W2069942756 @default.
- W1899016823 hasRelatedWork W2099053332 @default.
- W1899016823 hasRelatedWork W3203276856 @default.
- W1899016823 hasVolume "34" @default.
- W1899016823 isParatext "false" @default.
- W1899016823 isRetracted "false" @default.
- W1899016823 magId "1899016823" @default.
- W1899016823 workType "article" @default.