FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899018311> ?p ?o ?g. }

• W1899018311 abstract "Infantile colic is a common disorder in the first months of life, affecting somewhere between 4% and 28% of infants worldwide, depending on geography and definitions used. Although it is self limiting and resolves by four months of age, colic is perceived by parents as a problem that requires action. Pain-relieving agents, such as drugs, sugars and herbal remedies, have been suggested as interventions to reduce crying episodes and severity of symptoms.To assess the effectiveness and safety of pain-relieving agents for reducing colic in infants younger than four months of age.We searched the following databases in March 2015 and again in May 2016: CENTRAL, Ovid MEDLINE, Embase and PsycINFO, along with 11 other databases. We also searched two trial registers, four thesis repositories and the reference lists of relevant studies to identify unpublished and ongoing studies.We included randomised controlled trials (RCTs) and quasi-RCTs evaluating the effects of pain-relieving agents given to infants with colic.We used the standard methodological procedures of The Cochrane Collaboration.We included 18 RCTs involving 1014 infants. All studies were small and at high risk of bias, often presenting major shortcomings across multiple design factors (e.g. selection, performance, attrition, lack of washout period).Three studies compared simethicone with placebo, and one with Mentha piperita; four studies compared herbal agents with placebo; two compared sucrose or glucose with placebo; five compared dicyclomine with placebo; and two compared cimetropium - one against placebo and the other at two different dosages. One multiple-arm study compared sucrose and herbal tea versus no treatment. Simethicone. Comparison with placebo revealed no difference in daily hours of crying reported for simethicone at the end of treatment in one small, low-quality study involving 27 infants. A meta-analysis of data from two cross-over studies comparing simethicone with placebo showed no difference in the number of of infants who responded positively to treatment (risk ratio (RR) 0.95, 95% confidence interval (CI) 0.73 to 1.23; 110 infants, low-quality evidence).One small study (30 participants) compared simethicone with Mentha piperita and found no difference in crying duration, number of crying episodes or number of responders. Herbal agents. We found low-quality evidence suggesting that herbal agents reduce the duration of crying compared with placebo (mean difference (MD) 1.33, 95% CI 0.71 to 1.96; three studies, 279 infants), with different magnitude of benefit noted across studies (I² = 96%). We found moderate-quality evidence indicating that herbal agents increase response over placebo (RR 2.05, 95% CI 1.56 to 2.70; three studies, 277 infants). Sucrose. One very low-quality study involving 35 infants reported that sucrose reduced hours spent crying compared with placebo (MD 1.72, 95% CI 1.38 to 2.06). Dicyclomine. We could consider only one of the five studies of dicyclomine (48 infants) for the primary comparison. In this study, more of the infants given dicyclomine responded than than those given placebo (RR 2.50, 95% CI 1.17 to 5.34). Cimetropium bromide. Data from one very low-quality study comparing cimetropium bromide with placebo showed reduced crying duration among infants treated with cimetropium bromide (MD -30.20 minutes per crisis, 95% CI -39.51 to -20.89; 86 infants). The same study reported that cimetropium increased the number of responders (RR 2.29, 95% CI 1.44 to 3.64).No serious adverse events were reported for all of the agents considered, with the exception of dicyclomine, for which two of five studies reported relevant adverse effects (longer sleep 4%, wide-eyed state 4%, drowsiness 13%).At the present time, evidence of the effectiveness of pain-relieving agents for the treatment of infantile colic is sparse and prone to bias. The few available studies included small sample sizes, and most had serious limitations. Benefits, when reported, were inconsistent.We found no evidence to support the use of simethicone as a pain-relieving agent for infantile colic.Available evidence shows that herbal agents, sugar, dicyclomine and cimetropium bromide cannot be recommended for infants with colic.Investigators must conduct RCTs using standardised measures that allow comparisons among pain-relieving agents and pooling of results across studies. Parents, who most often provide the intervention and assess the outcome, should always be blinded." @default.
• W1899018311 created "2016-06-24" @default.
• W1899018311 creator A5031454086 @default.
• W1899018311 creator A5032730169 @default.
• W1899018311 creator A5052337178 @default.
• W1899018311 creator A5060728338 @default.
• W1899018311 creator A5073631947 @default.
• W1899018311 date "2016-09-16" @default.
• W1899018311 modified "2023-10-11" @default.
• W1899018311 title "Pain-relieving agents for infantile colic" @default.
• W1899018311 cites W1153700157 @default.
• W1899018311 cites W13657528 @default.
• W1899018311 cites W1527867417 @default.
• W1899018311 cites W1538195844 @default.
• W1899018311 cites W1546847154 @default.
• W1899018311 cites W1594885476 @default.
• W1899018311 cites W1596902544 @default.
• W1899018311 cites W1625937990 @default.
• W1899018311 cites W169325666 @default.
• W1899018311 cites W1899018311 @default.
• W1899018311 cites W1936866177 @default.
• W1899018311 cites W1944323464 @default.
• W1899018311 cites W195776815 @default.
• W1899018311 cites W1964691563 @default.
• W1899018311 cites W1966193833 @default.
• W1899018311 cites W1967010630 @default.
• W1899018311 cites W1970375149 @default.
• W1899018311 cites W1971134853 @default.
• W1899018311 cites W1981408807 @default.
• W1899018311 cites W1985076798 @default.
• W1899018311 cites W1985478838 @default.
• W1899018311 cites W1986414596 @default.
• W1899018311 cites W1986799280 @default.
• W1899018311 cites W1989654169 @default.
• W1899018311 cites W1994167770 @default.
• W1899018311 cites W2000710385 @default.
• W1899018311 cites W2001244996 @default.
• W1899018311 cites W2006534849 @default.
• W1899018311 cites W2011407276 @default.
• W1899018311 cites W2011962742 @default.
• W1899018311 cites W2012853535 @default.
• W1899018311 cites W2018107864 @default.
• W1899018311 cites W2019610270 @default.
• W1899018311 cites W2021837715 @default.
• W1899018311 cites W2021944691 @default.
• W1899018311 cites W2029526086 @default.
• W1899018311 cites W2035419171 @default.
• W1899018311 cites W2037444265 @default.
• W1899018311 cites W2038574658 @default.
• W1899018311 cites W2040244187 @default.
• W1899018311 cites W2040680839 @default.
• W1899018311 cites W2044030748 @default.
• W1899018311 cites W2044309546 @default.
• W1899018311 cites W2047586716 @default.
• W1899018311 cites W2048563408 @default.
• W1899018311 cites W2051918224 @default.
• W1899018311 cites W2056736970 @default.
• W1899018311 cites W2061136783 @default.
• W1899018311 cites W2062488854 @default.
• W1899018311 cites W2066335266 @default.
• W1899018311 cites W2067269352 @default.
• W1899018311 cites W2068959829 @default.
• W1899018311 cites W2075183860 @default.
• W1899018311 cites W2078110114 @default.
• W1899018311 cites W2078239171 @default.
• W1899018311 cites W2078880833 @default.
• W1899018311 cites W2079163066 @default.
• W1899018311 cites W2087491986 @default.
• W1899018311 cites W2089210053 @default.
• W1899018311 cites W2093225468 @default.
• W1899018311 cites W2093589092 @default.
• W1899018311 cites W2101862113 @default.
• W1899018311 cites W2105004906 @default.
• W1899018311 cites W2105535342 @default.
• W1899018311 cites W2107859942 @default.
• W1899018311 cites W2109888167 @default.
• W1899018311 cites W2111725433 @default.
• W1899018311 cites W2116540885 @default.
• W1899018311 cites W2118718487 @default.
• W1899018311 cites W2120931944 @default.
• W1899018311 cites W2123206047 @default.
• W1899018311 cites W2123592452 @default.
• W1899018311 cites W2130235475 @default.
• W1899018311 cites W2136909898 @default.
• W1899018311 cites W2143202861 @default.
• W1899018311 cites W2145346043 @default.
• W1899018311 cites W2147614571 @default.
• W1899018311 cites W2149501466 @default.
• W1899018311 cites W2149862231 @default.
• W1899018311 cites W2150021025 @default.
• W1899018311 cites W2154312432 @default.
• W1899018311 cites W2155631217 @default.
• W1899018311 cites W2158069915 @default.
• W1899018311 cites W2165010366 @default.
• W1899018311 cites W2171758627 @default.
• W1899018311 cites W2182511308 @default.
• W1899018311 cites W2317925026 @default.
• W1899018311 cites W2326788466 @default.
• W1899018311 cites W2406720358 @default.
• W1899018311 cites W2408179687 @default.

• next