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- W1899169621 abstract "Abstract A technique for determining pepsinogen group I (PGI) concentrations in endoscopic gastroduodenal biopsies is described and validated. This method has a good precision (intra-assay CVs 4.1% to 8.4%; between-assay CVs 4.6% to 9.3%), and analytical recovery is satisfactory (94% to 102%). Results were uninfluenced by the storage interval of the samples. At PGI-producing sites (i.e., fundus, corpus) peptic activity was greater than in the antrum and duodenum. PGI concentrations in serum and in gastroduodenal biopsies were not correlated. This simple, reliable method can quantify better than other assays peptic activity in humans, without being influenced by gastric secretory volumes. It will also facilitate prospective studies on the effect of various secretagogues in vivo and evaluations of the influence of anti-ulcer drugs on peptic secretion." @default.
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- W1899169621 date "1990-04-01" @default.
- W1899169621 modified "2023-10-18" @default.
- W1899169621 title "Measurement of pepsinogen group I in endoscopic gastroduodenal biopsies" @default.
- W1899169621 doi "https://doi.org/10.1093/clinchem/36.4.682" @default.
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