Matches in SemOpenAlex for { <https://semopenalex.org/work/W1899218240> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1899218240 startingPage "2269" @default.
- W1899218240 abstract "Background: Quantitative CT can describe COPD heterogeneity; Percentile 15(perc15) describes emphysema, Mean Lung DensityE/I (MLD E/I) is a surrogate measure of small airways disease and Percentage Wall Area(%WA) reflects bronchial wall thickness. We hypothesised that CT measures independently influence disease severity defined by FEV1%predicted (FEV1%)Methods: All patients had a full inspiratory/expiratory CT and pulmonary function tests. Associations between CT parameters and lung function were explored.Results: 65 patients; 68% were male, with mean(SEM) age 68(1), FEV1% 52(2)% and FEV1/FVC ratio 51(1)%. Significant correlations (p<0.0001) were observed between MLD E/I and RV% predicted (r=0.47), FRC% (r=0.491), FEV1% (r=-0.66) and FEV1/FVC ratio (r=-0.52). There were also significant correlations between Perc15 and RV% (r=-0.35,p=0.008), FRC% (r=-0.37, p=0.003), FEV1% (r=0.41, p=0.001), FEV1FVC ratio (r=0.51, p<0.0001) and KCO% (r=0.42, p=0.001). There were no significant correlations between %WA in RB1 and lung function measures. Standard multiple regression was performed with FEV1% as the dependent variable and MLD E/I and perc15 as independent variables. The model showed no violation of multicollinearity or homoscedasticity. MLD E/I and perc15 explained 36% of the variance in FEV1%. MLD E/I made the largest unique contribution (beta=-0.45, p<0.001), although perc15 also made a statistically significant contribution (beta=0.30, p=0.008).Conclusions: Emphysema and small airway measures independently contribute to disease severity defined by FEV1%, with small airways measures (MLD E/I) having a larger role." @default.
- W1899218240 created "2016-06-24" @default.
- W1899218240 creator A5021121714 @default.
- W1899218240 creator A5025398594 @default.
- W1899218240 creator A5035958478 @default.
- W1899218240 creator A5050691426 @default.
- W1899218240 creator A5054245789 @default.
- W1899218240 creator A5060569920 @default.
- W1899218240 creator A5064249073 @default.
- W1899218240 creator A5065038240 @default.
- W1899218240 creator A5074736045 @default.
- W1899218240 creator A5083284874 @default.
- W1899218240 date "2013-09-01" @default.
- W1899218240 modified "2023-09-24" @default.
- W1899218240 title "Quantitative CT in COPD MAP: Emphysema and small airways disease independently contribute to FEV1" @default.
- W1899218240 hasPublicationYear "2013" @default.
- W1899218240 type Work @default.
- W1899218240 sameAs 1899218240 @default.
- W1899218240 citedByCount "0" @default.
- W1899218240 crossrefType "journal-article" @default.
- W1899218240 hasAuthorship W1899218240A5021121714 @default.
- W1899218240 hasAuthorship W1899218240A5025398594 @default.
- W1899218240 hasAuthorship W1899218240A5035958478 @default.
- W1899218240 hasAuthorship W1899218240A5050691426 @default.
- W1899218240 hasAuthorship W1899218240A5054245789 @default.
- W1899218240 hasAuthorship W1899218240A5060569920 @default.
- W1899218240 hasAuthorship W1899218240A5064249073 @default.
- W1899218240 hasAuthorship W1899218240A5065038240 @default.
- W1899218240 hasAuthorship W1899218240A5074736045 @default.
- W1899218240 hasAuthorship W1899218240A5083284874 @default.
- W1899218240 hasConcept C105795698 @default.
- W1899218240 hasConcept C122048520 @default.
- W1899218240 hasConcept C126322002 @default.
- W1899218240 hasConcept C164705383 @default.
- W1899218240 hasConcept C2776780178 @default.
- W1899218240 hasConcept C2777714996 @default.
- W1899218240 hasConcept C3018587741 @default.
- W1899218240 hasConcept C33923547 @default.
- W1899218240 hasConcept C48921125 @default.
- W1899218240 hasConcept C71924100 @default.
- W1899218240 hasConcept C75603125 @default.
- W1899218240 hasConceptScore W1899218240C105795698 @default.
- W1899218240 hasConceptScore W1899218240C122048520 @default.
- W1899218240 hasConceptScore W1899218240C126322002 @default.
- W1899218240 hasConceptScore W1899218240C164705383 @default.
- W1899218240 hasConceptScore W1899218240C2776780178 @default.
- W1899218240 hasConceptScore W1899218240C2777714996 @default.
- W1899218240 hasConceptScore W1899218240C3018587741 @default.
- W1899218240 hasConceptScore W1899218240C33923547 @default.
- W1899218240 hasConceptScore W1899218240C48921125 @default.
- W1899218240 hasConceptScore W1899218240C71924100 @default.
- W1899218240 hasConceptScore W1899218240C75603125 @default.
- W1899218240 hasLocation W18992182401 @default.
- W1899218240 hasOpenAccess W1899218240 @default.
- W1899218240 hasPrimaryLocation W18992182401 @default.
- W1899218240 hasRelatedWork W1967957900 @default.
- W1899218240 hasRelatedWork W2102860836 @default.
- W1899218240 hasRelatedWork W2355842159 @default.
- W1899218240 hasRelatedWork W2552831239 @default.
- W1899218240 hasRelatedWork W2555189292 @default.
- W1899218240 hasRelatedWork W2564472934 @default.
- W1899218240 hasRelatedWork W2582351239 @default.
- W1899218240 hasRelatedWork W2612520020 @default.
- W1899218240 hasRelatedWork W2725091558 @default.
- W1899218240 hasRelatedWork W2755711919 @default.
- W1899218240 hasRelatedWork W2791751160 @default.
- W1899218240 hasRelatedWork W2966099566 @default.
- W1899218240 hasRelatedWork W3024174486 @default.
- W1899218240 hasRelatedWork W3029951712 @default.
- W1899218240 hasRelatedWork W3030105555 @default.
- W1899218240 hasRelatedWork W3030232449 @default.
- W1899218240 hasRelatedWork W3030642304 @default.
- W1899218240 hasRelatedWork W3031247381 @default.
- W1899218240 hasRelatedWork W3158429837 @default.
- W1899218240 hasRelatedWork W1944840183 @default.
- W1899218240 hasVolume "42" @default.
- W1899218240 isParatext "false" @default.
- W1899218240 isRetracted "false" @default.
- W1899218240 magId "1899218240" @default.
- W1899218240 workType "article" @default.