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- W1899300904 abstract "Abstract T cell polarization toward and within the cellular interface with an APC is critical for effective T cell activation. The Rho family GTPase Cdc42 is a central regulator of cellular polarization. Using live-cell imaging, we characterized the spatiotemporal patterns of Cdc42 activity and their physiological regulation. Using three independent means of experimental manipulation of Cdc42 activity, we established that Cdc42 is a critical regulator of T cell actin dynamics, TCR clustering, and cell cycle entry. Using quantification of three-dimensional data, we could relate distinct spatiotemporal patterns of Cdc42 activity to specific elements of T cell activation. This result suggests that Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation." @default.
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- W1899300904 date "2006-08-01" @default.
- W1899300904 modified "2023-10-01" @default.
- W1899300904 title "Specific Patterns of Cdc42 Activity Are Related to Distinct Elements of T Cell Polarization" @default.
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- W1899300904 doi "https://doi.org/10.4049/jimmunol.177.3.1708" @default.
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