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- W1899449081 abstract "The compatibility of cimetidine hydrochloride and cefoperazone sodium in 5% dextrose injection stored at two temperatures was studied. Cimetidine hydrochloride and cefoperazone sodium were reconstituted or diluted with 5% dextrose injection to form an admixture with a cimetidine concentration of 2 mg/mL and a cefoperazone concentration of 5 mg/mL. The admixture was stored in 100-mL vented i.v. containers in the dark at 4 and 25 degrees C; three containers were stored at each temperature. A 2-mL sample was taken from each container after 0.5, 0.75, 1, 6, 12, 24, and 48 hours of storage and visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for each storage condition. At both temperatures, drug concentrations varied by less than 5% during the study period. No color change, precipitation, or cloudiness was observed for any of the solutions under any of the storage conditions. Cefoperazone sodium 5.0 mg/mL and cimetidine hydrochloride 2.0 mg/mL in admixtures in 5% dextrose injection are stable for 48 hours at 4 and 25 degrees C." @default.
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- W1899449081 date "1991-01-01" @default.
- W1899449081 modified "2023-09-27" @default.
- W1899449081 title "Compatibility of cefoperazone sodium and cimetidine hydrochloride in 5% dextrose injection" @default.
- W1899449081 doi "https://doi.org/10.1093/ajhp/48.1.111" @default.
- W1899449081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2000866" @default.
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